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Biosynthetic enzyme analysis identifies a protective role for TLR4-acting gut microbial sulfonolipids in inflammatory bowel disease

Biosynthetic enzyme-guided disease correlation analysis reveals a negative correlation between SoL biosynthesis and IBDWe began by systematically investigating the biosynthetic potential of SoLs from 285,835 human gut...

Proteome-scale recombinant standards and a robust high-speed search engine to advance cross-linking MS-based interactomics

An XL-MS standard mimicking complex biological samplesOur XL-MS standard is based on human proteins or protein fragments produced in E. coli (see Supplementary Data 1 for a...

How to finish a PhD | Careers

‘Completing a PhD is probably one of the most stressful and rewarding things that you’ll ever do,’ says Angela Russell, a medicinal chemist and PhD supervisor at...

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DynaMight: estimating molecular motions with improved reconstruction from cryo-EM images

Description of conformational variabilityWe describe the ith of Nd particle images, yi, with the following forward model:$${y}_{i}={{{{mathcal{C}}}}}_{i}* {{{{bf{P}}}}}_{{phi }_{i},}f({{{varGamma }}}_{!{z}_{i}}({{{bf{x}}}})),$$ ...

Direct ketone synthesis from primary alcohols and alkenes enabled by a dual photo/cobalt catalysis

Ertl, P. & Schuhmann, T. A systematic cheminformatics analysis of functional groups occurring in natural products. J. Nat. Prod. 82, 1258–1263 (2019).Article  ...

AI models trained on AI-generated data could spiral into unintelligible nonsense, scientists warn

Artificial Intelligence (AI) systems could slowly trend toward filling the internet with incomprehensible nonsense, new research has warned. AI models such as GPT-4, which powers...

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