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Population variability in X-chromosome inactivation across 10 mammalian species

Reference aligned RNA-sequencing data enables scalable modeling of XCI ratiosWe use bulk RNA-sequencing (RNA-seq) data to measure the X-linked allelic expression of a sampled...

The integrated molecular and histological analysis defines subtypes of esophageal squamous cell carcinoma

Transcriptomics subtypes of ESCC with distinct prognosisTo fully understand the transcriptomic heterogeneity and molecular signatures of ESCC associated with differences in prognosis, we investigated...

BioNumPy: array programming for biology

Python is a widely used programming language for scientific computing, in large part due to the powerful array programming library NumPy1, which makes it...

Modelling the spatial variability and uncertainty for under-vaccination and zero-dose children in fragile settings

World Health Organization. Immunization Agenda 2030: A Global Strategy To Leave No One Behind. (Geneva, 2021).GAVI. Prevent, Protect Prosper. (Geneva, 2021).UN. The Sustainable Development...

Image processing tools for petabyte-scale light sheet microscopy data

Generic computing frameworkOur generic computing framework supports both single machines and large-scale Slurm-based computing clusters with CPU and/or GPU node configurations. The conductor job...

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