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Biosynthetic enzyme analysis identifies a protective role for TLR4-acting gut microbial sulfonolipids in inflammatory bowel disease

Biosynthetic enzyme-guided disease correlation analysis reveals a negative correlation between SoL biosynthesis and IBDWe began by systematically investigating the biosynthetic potential of SoLs from 285,835 human gut...

A long-context language model for deciphering and generating bacteriophage genomes

megaDNA allows zero-shot prediction of gene essentialityTo construct the training dataset, we collected bacteriophage genomes with high confidence from three sources including the NCBI GenBank, the metagenomic...

Multiomic analysis of familial adenomatous polyposis reveals molecular pathways associated with early tumorigenesis

Multiomic analysis of FAP samplesWe collected and analyzed n = 93 samples from the colons of six persons with FAP whose characteristics are shown in Table 1. The samples...

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Occlusion enhanced pan-cancer classification via deep learning | BMC Bioinformatics

Xia C, Dong X, Li H, Cao M, Sun D, He S, Yang F, Yan X, Zhang S, Li N. Cancer statistics in China...

XPS depth profiling of nano-layers by a novel trial-and-error evaluation procedure

Simulation of the XPS depth profile of pristine sampleThe structure of the pristine sample has been determined previously16,19. It is: 10.5 nm C/24.5 nm W/9 nm C/2 nm...

DynaMight: estimating molecular motions with improved reconstruction from cryo-EM images

Description of conformational variabilityWe describe the ith of Nd particle images, yi, with the following forward model:$${y}_{i}={{{{mathcal{C}}}}}_{i}* {{{{bf{P}}}}}_{{phi }_{i},}f({{{varGamma }}}_{!{z}_{i}}({{{bf{x}}}})),$$ ...

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