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Structural insights into the inhibition mechanism of fungal GWT1 by manogepix

Characterization of yeast GWT1We purified the full-length yeast GWT1 using Sf9 cells (Supplementary Fig. 3a). Cryo-EM analysis revealed well-dispersed particles. However, small protein size and lack of distinct...

Ubiquitin-related gene markers predict immunotherapy response and prognosis in patients with epithelial ovarian carcinoma

Siegel, R. L., Miller, K. D., Wagle, N. S. & Jemal, A. Cancer statistics, 2023. CA Cancer J. Clin. 73 (1), 17–48 (2023).Article  ...

Identification of metabolic biomarkers in idiopathic pulmonary arterial hypertension using targeted metabolomics and bioinformatics analysis

Recent research has increasingly highlighted the role of metabolomics in understanding PAH. Metabolomics provides a unique vantage point to examine the perturbations in small molecule metabolites that...

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Tiny graphene-based magnetic devices could lead to much smaller — and way more powerful — processors in the future

Researchers have developed a technique that could enable the extreme miniaturization of computing components, paving the way for compact and high-performance devices.The smaller the...

The threat of mpox has returned, but public knowledge about it has declined

It has been two years since the World Health Organization declared a global health emergency over an outbreak of mpox, a disease endemic to...

Ask us anything: what breakthrough in ecological theory could have the biggest impact for applied conservation?

Recently we invited you to ask us anything. Today’s question comes from Falko Buschke, who asks (paraphrasing) “What breakthrough in ecological theory could have...

Enhanced circularly polarized luminescence attained via self-assembly of heterochiral as opposed to homochiral dipeptides in water

Circularly polarized luminescence (CPL) is gaining interest across various disciplines, including materials...

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