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Shrinkage estimation of gene interaction networks in single-cell RNA sequencing data | BMC Bioinformatics

OverviewGraphical models are graphs in which nodes are random variables and the presence of edges represent conditional dependence or “direct links” between them . Two random variables,...

Predicting transcriptional responses to novel chemical perturbations using deep generative model for drug discovery

PRnet: perturbation-conditioned deep generative model for transcriptional response predictionIn this paper, we formulate the transcriptional response prediction as a distribution generation problem conditioned on perturbations. Cells inherently...

Identification of diagnostic markers pyrodeath-related genes in non-alcoholic fatty liver disease based on machine learning and experiment validation

Cusi, K. et al. Non-alcoholic fatty liver disease (NAFLD) prevalence and its metabolic associations in patients with type 1 diabetes and type 2 diabetes. Diabetes Obes. Metab....

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CHD4 R975H mutant activates tumorigenic pathways and promotes stemness and M2-like macrophage polarization in endometrial cancer

CHD4 mutation occurs frequently in endometrial cancerThe frequency of CHD4 mutations in endometrial cancer was systematically investigated by analysing data from various databases associated...

Glimpse into the nanoworld: Microscope reveals tiniest cell processes

What does the inside of a cell really look like? In the past, standard microscopes were limited in how well they could answer this...

A common parasite could deliver drugs to the brain—how scientists are turning Toxoplasma gondii from foe into friend

Parasites take an enormous toll on human and veterinary health. But researchers may have found a way for patients with brain disorders and a...

Asthma emergencies spike when allergenic pollen blooms

A new Cornell University study that tracks how many asthma-related emergency room visits result from pollen in metropolitan areas highlights the importance of knowing...

Breakthrough study reveals molecular subtypes of Down syndrome, offering insights for personalized medicine approaches

A new study published in Nature Communications by researchers from the Linda Crnic Institute for Down Syndrome (Crnic Institute) at the University of Colorado...

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