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Predicting transcriptional responses to novel chemical perturbations using deep generative model for drug discovery

PRnet: perturbation-conditioned deep generative model for transcriptional response predictionIn this paper, we formulate the transcriptional response prediction as a distribution generation problem conditioned on perturbations. Cells inherently...

Virtual resection evaluation based on sEEG propagation network for drug-resistant epilepsy

PatientsWe used two datasets: (1) Clinical data with 6 patients with 12 seizures from the neurosurgery department of Shanxi Provincial People’s Hospital; (2) HUP data with 10...

Identification of diagnostic markers pyrodeath-related genes in non-alcoholic fatty liver disease based on machine learning and experiment validation

Cusi, K. et al. Non-alcoholic fatty liver disease (NAFLD) prevalence and its metabolic associations in patients with type 1 diabetes and type 2 diabetes. Diabetes Obes. Metab....

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Breakthrough study reveals molecular subtypes of Down syndrome, offering insights for personalized medicine approaches

A new study published in Nature Communications by researchers from the Linda Crnic Institute for Down Syndrome (Crnic Institute) at the University of Colorado...

IrCytoToxDB: a dataset of iridium(III) complexes cytotoxicities against various cell lines

Zysman-Colman, E. Iridium (III) in optoelectronic and photonics applications (John Wiley & Sons, 2017).Jayabharathi, J., Thanikachalam, V. & Thilagavathy, S. Phosphorescent organic light-emitting devices:...

Mix of factors prompts owl monkeys to leave their parents

There comes a point in the lives of young owl monkeys when they leave their parents and strike out on their own to find...

Physics-informed deep generative learning for quantitative assessment of the retina

Procedural generation of synthetic retinal vasculatureAlgorithms for generating synthetic retinas followed multiple, length scale dependent steps66. Firstly, the values of geometrical parameters were set...

Electrodeposition of porous metal-organic frameworks for efficient charge storage

The electrodeposition technique was employed to deposit Co-MOFs on a nickel foam substrate using Co2+ metal ions and 1,2 benzene dicarboxylic acid in a...

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