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Differential amino acid usage leads to ubiquitous edge effect in proteomes across domains of life that can be explained by amino acid secondary structure...

Proteomes differ among distant domains of lifeTwo competing hypotheses suggest that amino acid usage in proteomes differ or not among distant groups of living organisms. The lineage-specific...

Virtual resection evaluation based on sEEG propagation network for drug-resistant epilepsy

PatientsWe used two datasets: (1) Clinical data with 6 patients with 12 seizures from the neurosurgery department of Shanxi Provincial People’s Hospital; (2) HUP data with 10...

Identification of diagnostic markers pyrodeath-related genes in non-alcoholic fatty liver disease based on machine learning and experiment validation

Cusi, K. et al. Non-alcoholic fatty liver disease (NAFLD) prevalence and its metabolic associations in patients with type 1 diabetes and type 2 diabetes. Diabetes Obes. Metab....

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Scientists uncover hidden forces causing continents to rise

Scientists at the University of Southampton have answered one of the most puzzling questions in plate tectonics: how and why 'stable' parts of continents...

Fishing is causing frightened fish to flee when they should flirt

Populations of squaretail grouper face an uncertain future as new research shows fishing that targets their spawning sites is causing males to be repeatedly...

Molecule restores cognition, memory in Alzheimer’s disease model mice

In a new study, a molecule identified and synthesized by UCLA Health researchers was shown to restore cognitive functions in mice with symptoms of...

4-Vinylpyridine copolymers for improved LC–MS tryptophan and kynurenine determination in human serum

Reagents and materialsAcetonitrile (ACN), dimethyl sulfoxide (DMSO), HCl, CH3COOH (suprapur®), KH2PO4, and normal human serum were purchased from Merck (Darmstadt, Germany). Crystalline l-Trp (≥ 98%),...

Memory loss in aging and dementia: Dendritic spine head diameter predicts memory in old age

Over the course of life, memory fades with varying degrees, robbing older people of the ability to recollect personal experiences. This progressive, nearly inevitable...

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