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Comprehensive evaluation and prediction of editing outcomes for near-PAMless adenine and cytosine base editors

Generation of near-PAMless base editorsTo leverage the expanded PAM compatibility offered by SpRY, our study utilized the BE4max-SpRY and ABEmax-SpRY, which incorporate SpRY in place of SpCas9,...

The prominent pervasive oncogenic role and tissue specific permissiveness of RAS gene mutations

Data mining of CRISPR effect scores in DepMap showed prevalent difference in RAS genes between mutant lines vs. WT lines but also revealed drawbacks of individual assessment...

Multiple cell types including melanocytes contribute to elastogenesis in the developing murine aortic valve

Aortic valve eln expression peaks in early postnatal stagesTo assess the timeline of Eln expression, murine WT AoVs were isolated from various embryonic stages beginning from E13.5...

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How rising fuel prices affect the use of bike sharing in cities?

Urban transportation is a critical component in the development of sustainable cities. Bicycle sharing...

Struggling with a creative task? ChatGPT may help

US scientists decided to ask ChatGPT to help people recruited online with a range of tasks that require a bit of creativity, including choosing a gift...

Machine learning assisted prediction of organic salt structure properties

Descriptor selectionWe minimize the random forest regressor model training errors by optimizing the number of descriptors to be used for model construction. An initial...

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