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Profiling the transcriptomic age of single-cells in humans

Description of the input datasetsThis study used publicly available datasets, all of which were produced by single-cell RNA sequencing of human cells (Supplementary Table 1). The collection and...

Multiple cell types including melanocytes contribute to elastogenesis in the developing murine aortic valve

Aortic valve eln expression peaks in early postnatal stagesTo assess the timeline of Eln expression, murine WT AoVs were isolated from various embryonic stages beginning from E13.5...

Comprehensive evaluation and prediction of editing outcomes for near-PAMless adenine and cytosine base editors

Generation of near-PAMless base editorsTo leverage the expanded PAM compatibility offered by SpRY, our study utilized the BE4max-SpRY and ABEmax-SpRY, which incorporate SpRY in place of SpCas9,...

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Struggling with a creative task? ChatGPT may help

US scientists decided to ask ChatGPT to help people recruited online with a range of tasks that require a bit of creativity, including choosing a gift...

Machine learning assisted prediction of organic salt structure properties

Descriptor selectionWe minimize the random forest regressor model training errors by optimizing the number of descriptors to be used for model construction. An initial...

Finding the neural pathways behind the placebo effect

Understanding the placebo effect could lead to pain management therapies that are more effective than opioids without causing addiction. Scientists have uncovered the neural circuit...

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