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Comprehensive evaluation and prediction of editing outcomes for near-PAMless adenine and cytosine base editors

Generation of near-PAMless base editorsTo leverage the expanded PAM compatibility offered by SpRY, our study utilized the BE4max-SpRY and ABEmax-SpRY, which incorporate SpRY in place of SpCas9,...

The prominent pervasive oncogenic role and tissue specific permissiveness of RAS gene mutations

Data mining of CRISPR effect scores in DepMap showed prevalent difference in RAS genes between mutant lines vs. WT lines but also revealed drawbacks of individual assessment...

Phytochemical composition, in vitro cytotoxicity, and in silico docking properties of Tamarix tetragyna L.

Ezeabara, C. A. & Egenti, M. O. Phytochemical and antimicrobial investigations on various parts of Sida acuta Burm. F. J. Ayurvedic Herb. Med. 4 (2), 71–75 (2018).Article  ...

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Dehydration regulates structural reorganization of dynamic hydrogels

In previous studies, the link between molecular behaviors and the macroscopic mechanical properties of dynamic hydrogels has been demonstrated17. A scaling relationship between water...

How rising fuel prices affect the use of bike sharing in cities?

Urban transportation is a critical component in the development of sustainable cities. Bicycle sharing...

Struggling with a creative task? ChatGPT may help

US scientists decided to ask ChatGPT to help people recruited online with a range of tasks that require a bit of creativity, including choosing a gift...

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