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Self-supervised learning for accurately modelling hierarchical evolutionary patterns of cerebrovasculature

FrameworkThe proposed pipeline for hierarchical quantitative analysis of cerebrovasculature is illustrated in Fig. 1. Paired T1 and TOF-MRA images were acquired from each subject. TOF-MRA volumes were utilized...

Comprehensive evaluation and prediction of editing outcomes for near-PAMless adenine and cytosine base editors

Generation of near-PAMless base editorsTo leverage the expanded PAM compatibility offered by SpRY, our study utilized the BE4max-SpRY and ABEmax-SpRY, which incorporate SpRY in place of SpCas9,...

The prominent pervasive oncogenic role and tissue specific permissiveness of RAS gene mutations

Data mining of CRISPR effect scores in DepMap showed prevalent difference in RAS genes between mutant lines vs. WT lines but also revealed drawbacks of individual assessment...

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Buddhas of Bamiyan: The colossal twin statues that stood sentinel over Afghanistan — until the Taliban destroyed them

Name: Buddhas of BamiyanWhat they are: Two monumental statues carved into the sides of sandstone cliffsWhere they are from: Bamiyan Valley, in central AfghanistanWhen...

Atom-pair engineering of single-atom nanozyme for boosting peroxidase-like activity

Synthesis and characterization of Zn-based SAzymesAs shown in Fig. 1a, the Zn-SA/CNCl SAzyme was synthesized by the NaCl-co-pyrolysis strategy, during which NaCl and Zeolite Imidazole...

The irregular habits of crystals | Feature

‘Defects’ are the main bugbear in the amorphous materials used as dielectrics in microelectronics – an industry that gives these materials a sharply rising...

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