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Interpretable GWAS by linking clinical phenotypes to quantifiable immune repertoire components

Genome-wide association of TCR repertoire unitsWe analyzed a cohort comprising both whole genome sequencing (WGS) and longitudinal peripheral blood RNA sequencing (RNA-seq) data (rfuQTL training set; Supplementary...

Benchmarking machine learning methods for synthetic lethality prediction in cancer

Benchmarking pipelineTo evaluate machine learning methods for predicting SL interactions, we selected 12 methods published in recent years, including three matrix factorization-based methods (SL2MF31, CMFW32, and GRSMF33)...

Enhanced stereodivergent evolution of carboxylesterase for efficient kinetic resolution of near-symmetric esters through machine learning

Development of a high-throughput method to obtain a high-quality enantioselectivity datasetEnantiomeric excess (e.e.) is a commonly used parameter to gauge the enantioselectivity of given enzymes. However, when...

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Life for a bumblebee queen isn’t always regal, nor cushy. In the spring, she starts to build her colony. But before that, she must...

Understanding our brains is complicated, beware of simple ideas | Opinion

Is there a bigger meeting of minds than in research into our own minds? Trying to understand our brains is one of the most...

Nanoparticles disrupt placenta, potentially affecting fetal development

Nanoparticles disrupted the placenta's secretion of biomolecules essential for blood vessel growth, hormone production, and immune function. Researchers have shown that nanoparticles found in the...

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