Seluanov, A., Gladyshev, V. N., Vijg, J. & Gorbunova, V. Mechanisms of cancer resistance in long-lived mammals. Nat. Rev. Cancer 18, 433–441 (2018).Article
CAS
PubMed
PubMed Central
Google Scholar
Wang, L. F., Walker, P. J. & Poon, L. L. Mass extinctions, biodiversity and mitochondrial function: are bats ‘special’ as reservoirs for emerging viruses? Curr. Opin. Virol. 1, 649–657 (2011).Article
CAS
PubMed
PubMed Central
Google Scholar
Koh, J. et al. ABCB1 protects bat cells from DNA damage induced by genotoxic compounds. Nat. Commun. 10, 2820 (2019).Article
PubMed
PubMed Central
Google Scholar
Bart, J. et al. The distribution of drug-efflux pumps, P-gp, BCRP, MRP1 and MRP2, in the normal blood–testis barrier and in primary testicular tumours. Eur. J. Cancer 40, 2064–2070 (2004).Article
CAS
PubMed
Google Scholar
Cascorbi, I. P-glycoprotein: tissue distribution, substrates, and functional consequences of genetic variations. Handb. Exp. Pharmacol. 201, 261–283 (2011).Schinkel, A. H. et al. Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins. Proc. Natl Acad. Sci. USA 94, 4028–4033 (1997).Article
CAS
PubMed
PubMed Central
Google Scholar
Szakacs, G. et al. Predicting drug sensitivity and resistance: profiling ABC transporter genes in cancer cells. Cancer Cell 6, 129–137 (2004).Article
CAS
PubMed
Google Scholar
Bugde, P. et al. The therapeutic potential of targeting ABC transporters to combat multi-drug resistance. Expert Opin. Therapeutic Targets 21, 511–530 (2017).Article
Google Scholar
Briz, O. et al. What “The Cancer Genome Atlas” database tells us about the role of ATP-binding cassette (ABC) proteins in chemoresistance to anticancer drugs. Expert Opin. Drug Metab. Toxicol. 15, 577–593 (2019).Article
CAS
PubMed
Google Scholar
Nemethova, V. & Razga, F. Overexpression of ABCB1 as prediction marker for CML: how close we are to translation into clinics? Leukemia 31, 266–267 (2017).Article
CAS
PubMed
Google Scholar
Robey, R. W. et al. Revisiting the role of ABC transporters in multidrug-resistant cancer. Nat. Rev. Cancer 18, 452–464 (2018).Article
CAS
PubMed
PubMed Central
Google Scholar
Dantzic, D. et al. The effects of synthetically modified natural compounds on ABC transporters. Pharmaceutics 10, 127 (2018).Article
CAS
PubMed
PubMed Central
Google Scholar
Begicevic, R. R. & Falasca, M. ABC transporters in cancer stem cells: beyond chemoresistance. Int J. Mol. Sci. 18, 2362 (2017).Article
PubMed
PubMed Central
Google Scholar
Fletcher, J. I., Haber, M., Henderson, M. J. & Norris, M. D. ABC transporters in cancer: more than just drug efflux pumps. Nat. Rev. Cancer 10, 147–156 (2010).Article
CAS
PubMed
Google Scholar
Leonard, G. D., Fojo, T. & Bates, S. E. The role of ABC transporters in clinical practice. Oncologist 8, 411–424 (2003).Article
CAS
PubMed
Google Scholar
Leonard, G. D., Polgar, O. & Bates, S. E. ABC transporters and inhibitors: new targets, new agents. Curr. Opin. Investig. Drugs 3, 1652–1659 (2002).CAS
PubMed
Google Scholar
Binkhathlan, Z. & Lavasanifar, A. P-glycoprotein inhibition as a therapeutic approach for overcoming multidrug resistance in cancer: current status and future perspectives. Curr. Cancer Drug Targets 13, 326–346 (2013).Article
CAS
PubMed
Google Scholar
Alam, A. et al. Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1. Proc. Natl Acad. Sci. USA 115, E1973–E1982 (2018).Article
CAS
PubMed
PubMed Central
Google Scholar
Kim, Y. & Chen, J. Molecular structure of human P-glycoprotein in the ATP-bound, outward-facing conformation. Science 359, 915–919 (2018).Article
CAS
PubMed
Google Scholar
Dastvan, R., Mishra, S., Peskova, Y. B., Nakamoto, R. K. & McHaourab, H. S. Mechanism of allosteric modulation of P-glycoprotein by transport substrates and inhibitors. Science 364, 689–692 (2019).Article
CAS
PubMed
PubMed Central
Google Scholar
Alam, A., Kowal, J., Broude, E., Roninson, I. & Locher, K. P. Structural insight into substrate and inhibitor discrimination by human P-glycoprotein. Science 363, 753–756 (2019).Article
CAS
PubMed
PubMed Central
Google Scholar
Nosol, K. et al. Cryo-EM structures reveal distinct mechanisms of inhibition of the human multidrug transporter ABCB1. Proc. Natl Acad. Sci. USA 117, 26245–26253 (2020).Article
CAS
PubMed
PubMed Central
Google Scholar
Hawkins, J. A. et al. A metaanalysis of bat phylogenetics and positive selection based on genomes and transcriptomes from 18 species. Proc. Natl Acad. Sci. USA 116, 11351–11360 (2019).Article
CAS
PubMed
PubMed Central
Google Scholar
Klaessens, S., Stroobant, V., De Plaen, E. & Van den Eynde, B. J. Systemic tryptophan homeostasis. Front Mol. Biosci. 9, 897929 (2022).Article
CAS
PubMed
PubMed Central
Google Scholar
Sissung, T. M. et al. Pharmacogenetics of membrane transporters: an update on current approaches. Mol. Biotechnol. 44, 152–167 (2010).Article
CAS
PubMed
PubMed Central
Google Scholar
Yu, H., Xie, X. & Li, S. M. Coupling of guanine with cyclo-l-Trp-l-Trp mediated by a cytochrome P450 homologue from Streptomyces purpureus. Org. Lett. 20, 4921–4925 (2018).Article
CAS
PubMed
Google Scholar
Sun, C., Tian, W., Lin, Z. & Qu, X. Biosynthesis of pyrroloindoline-containing natural products. Nat. Prod. Rep. 39, 1721–1765 (2022).Article
CAS
PubMed
Google Scholar
Deletti, G. et al. Unveiling an indole alkaloid diketopiperazine biosynthetic pathway that features a unique stereoisomerase and multifunctional methyltransferase. Nat. Commun. 14, 2558 (2023).Article
CAS
PubMed
PubMed Central
Google Scholar
Khopade, T. M., Ajayan, K., Vincent, D. M., Lane, A. L. & Viswanathan, R. Biomimetic total synthesis of (+)-Nocardioazine B and analogs. J. Org. Chem. 87, 11519–11533 (2022).Article
CAS
PubMed
Google Scholar
Khopade, T. M., Ajayan, K., Joshi, S. S., Lane, A. L. & Viswanathan, R. Bioinspired bronsted acid-promoted regioselective tryptophan isoprenylations. ACS Omega 6, 10840–10858 (2021).Article
CAS
PubMed
PubMed Central
Google Scholar
Juliano, R. L. & Ling, V. A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. Biochim Biophys. Acta 455, 152–162 (1976).Article
CAS
PubMed
Google Scholar
Riordan, J. R. et al. Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines. Nature 316, 817–819 (1985).Article
CAS
PubMed
Google Scholar
Ueda, K., Cardarelli, C., Gottesman, M. M. & Pastan, I. Expression of a full-length cDNA for the human “MDR1” gene confers resistance to colchicine, doxorubicin, and vinblastine. Proc. Natl Acad. Sci. USA 84, 3004–3008 (1987).Article
CAS
PubMed
PubMed Central
Google Scholar
Chen, C. J. et al. Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells. Cell 47, 381–389 (1986).Article
CAS
PubMed
Google Scholar
Dean, M., Rzhetsky, A. & Allikmets, R. The human ATP-binding cassette (ABC) transporter superfamily. Genome Res. 11, 1156–1166 (2001).Article
CAS
PubMed
Google Scholar
Chufan, E. E., Sim, H. M. & Ambudkar, S. V. Molecular basis of the polyspecificity of P-glycoprotein (ABCB1): recent biochemical and structural studies. Adv. Cancer Res. 125, 71–96 (2015).Article
CAS
PubMed
PubMed Central
Google Scholar
Wong, K., Ma, J., Rothnie, A., Biggin, P. C. & Kerr, I. D. Towards understanding promiscuity in multidrug efflux pumps. Trends Biochem. Sci. 39, 8–16 (2014).Article
CAS
PubMed
Google Scholar
Haitham Abusara, O., Freeman, S. & Aojula, H. S. Pentapeptides for the treatment of small cell lung cancer: Optimisation by N(ind)-alkyl modification of the tryptophan side chain. Eur. J. Med. Chem. 137, 221–232 (2017).Article
CAS
PubMed
PubMed Central
Google Scholar
He, B., Song, H., Du, Y. & Qin, Y. Total synthesis of (-)-ardeemin. J. Org. Chem. 74, 298–304 (2009).Article
CAS
PubMed
Google Scholar
Alqahtani, N. et al. Synergism between genome sequencing, tandem mass spectrometry and bio-inspired synthesis reveals insights into nocardioazine B biogenesis. Org. Biomol. Chem. 13, 7177–7192 (2015).Article
CAS
PubMed
Google Scholar
Wilkinson, G. S. & South, J. M. Life history, ecology and longevity in bats. Aging Cell 1, 124–131 (2002).Article
CAS
PubMed
Google Scholar
Harper, J. M., Salmon, A. B., Leiser, S. F., Galecki, A. T. & Miller, R. A. Skin‐derived fibroblasts from long‐lived species are resistant to some, but not all, lethal stresses and to the mitochondrial inhibitor rotenone. Aging Cell 6, 1–13 (2007).Article
CAS
PubMed
Google Scholar
Ma, S. et al. Cell culture-based profiling across mammals reveals DNA repair and metabolism as determinants of species longevity. eLife 5, e19130 (2016).Article
PubMed
PubMed Central
Google Scholar
Oh, S.-H., Lee, S.-Y., Choi, C.-H., Lee, S.-H. & Lim, S.-C. Cadmium adaptation is regulated by multidrug resistance-associated protein-mediated Akt pathway and metallothionein induction. Arch. Pharm. Res. 32, 883–891 (2009).Article
CAS
PubMed
Google Scholar
Bansal, T., Jaggi, M., Khar, R. K. & Talegaonkar, S. Emerging significance of flavonoids as P-glycoprotein inhibitors in cancer chemotherapy. J. Pharm. Pharm. Sci. 12, 46–78 (2009).Article
CAS
PubMed
Google Scholar
Ueda, K. et al. Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone. J. Biol. Chem. 267, 24248–24252 (1992).Article
CAS
PubMed
Google Scholar
Foster, B. C. et al. An in vitro evaluation of human cytochrome P450 3A4 and P-glycoprotein inhibition by garlic. J. Pharm. Pharm. Sci. 4, 176–184 (2001).CAS
PubMed
Google Scholar
Jodoin, J., Demeule, M. & Beliveau, R. Inhibition of the multidrug resistance P-glycoprotein activity by green tea polyphenols. Biochim. Biophys. Acta 1542, 149–159 (2002).Article
CAS
PubMed
Google Scholar
Choi, C. H., Kang, G. & Min, Y. D. Reversal of P-glycoprotein-mediated multidrug resistance by protopanaxatriol ginsenosides from Korean red ginseng. Planta Med. 69, 235–240 (2003).Article
CAS
PubMed
Google Scholar
Honda, Y. et al. Effects of grapefruit juice and orange juice components on P-glycoprotein- and MRP2-mediated drug efflux. Br. J. Pharm. 143, 856–864 (2004).Article
CAS
Google Scholar
Li, W. et al. Overcoming ABC transporter-mediated multidrug resistance: molecular mechanisms and novel therapeutic drug strategies. Drug Resist Updat. 27, 14–29 (2016).Article
CAS
PubMed
Google Scholar
Amin, M. L. P-glycoprotein inhibition for optimal drug delivery. Drug Target Insights 7, 27–34 (2013).Article
PubMed
PubMed Central
Google Scholar
Di, L. & Kerns, E. H. Profiling drug-like properties in discovery research. Curr. Opin. Chem. Biol. 7, 402–408 (2003).Article
CAS
PubMed
Google Scholar
Loscher, W. & Potschka, H. Drug resistance in brain diseases and the role of drug efflux transporters. Nat. Rev. Neurosci. 6, 591–602 (2005).Article
PubMed
Google Scholar
Schinkel, A. et al. Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell 77, 491–502 (1994).Article
CAS
PubMed
Google Scholar
Cordon-Cardo, C. et al. Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites. Proc. Natl Acad. Sci. USA 86, 695–698 (1989).Article
CAS
PubMed
PubMed Central
Google Scholar
Wijaya, J., Fukuda, Y. & Schuetz, J. D. Obstacles to Brain Tumor Therapy: Key ABC Transporters. Int J. Mol. Sci. 18, E2544 (2017).Article
Google Scholar
Boulton, D. W., DeVane, C. L., Liston, H. L. & Markowitz, J. S. In vitro P-glycoprotein affinity for atypical and conventional antipsychotics. Life Sci. 71, 163–169 (2002).Article
CAS
PubMed
Google Scholar
Wang, J. S. et al. The brain entry of risperidone and 9-hydroxyrisperidone is greatly limited by P-glycoprotein. Int J. Neuropsychopharmacol. 7, 415–419 (2004).Article
CAS
PubMed
Google Scholar
Dutheil, F. et al. ABC transporters and cytochromes P450 in the human central nervous system: influence on brain pharmacokinetics and contribution to neurodegenerative disorders. Expert Opin. Drug Metab. Toxicol. 6, 1161–1174 (2010).Article
CAS
PubMed
Google Scholar
Hashiguchi, Y. et al. Role of P-glycoprotein in the efflux of raltegravir from human intestinal cells and CD4+ T-cells as an interaction target for anti-HIV agents. Biochem. Biophys. Res. Commun. 439, 221–227 (2013).Article
CAS
PubMed
Google Scholar
Profit, L., Eagling, V. A. & Back, D. J. Modulation of P-glycoprotein function in human lymphocytes and Caco-2 cell monolayers by HIV-1 protease inhibitors. AIDS 13, 1623–1627 (1999).Article
CAS
PubMed
Google Scholar
Lee, C. G. et al. HIV-1 protease inhibitors are substrates for the MDR1 multidrug transporter. Biochemistry 37, 3594–3601 (1998).Article
CAS
PubMed
Google Scholar
Sankatsing, S. U., Beijnen, J. H., Schinkel, A. H., Lange, J. M. & Prins, J. M. P glycoprotein in human immunodeficiency virus type 1 infection and therapy. Antimicrob. Agents Chemother. 48, 1073–1081 (2004).Article
CAS
PubMed
PubMed Central
Google Scholar
Zhang, J. C. et al. Expression levels of P-glycoprotein in peripheral blood CD8+ T lymphocytes from HIV-1-infected patients on antiretroviral therapy. Int J. Mol. Med. 33, 431–440 (2014).Article
PubMed
Google Scholar
Minuesa, G. et al. P-glycoprotein (ABCB1) activity decreases raltegravir disposition in primary CD4+P-gphigh cells and correlates with HIV-1 viral load. J. Antimicrob. Chemother. 71, 2782–2792 (2016).Article
CAS
PubMed
PubMed Central
Google Scholar
van Veen, H. W. et al. A bacterial antibiotic-resistance gene that complements the human multidrug-resistance P-glycoprotein gene. Nature 391, 291–295 (1998).Article
PubMed
Google Scholar
Crameri, G. et al. Establishment, immortalisation and characterisation of pteropid bat cell lines. PLoS ONE 4, e8266 (2009).Article
PubMed
PubMed Central
Google Scholar
Zhang, Q. et al. IFNAR2-dependent gene expression profile induced by IFN-alpha in Pteropus alecto bat cells and impact of IFNAR2 knockout on virus infection. PLoS ONE 12, e0182866 (2017).Article
PubMed
PubMed Central
Google Scholar
Kodan, A. et al. Inward- and outward-facing X-ray crystal structures of homodimeric P-glycoprotein CmABCB1. Nat. Commun. 10, 88 (2019).Article
CAS
PubMed
PubMed Central
Google Scholar
Hirayama, H., Kimura, Y., Kioka, N., Matsuo, M. & Ueda, K. ATPase activity of human ABCG1 is stimulated by cholesterol and sphingomyelin. J. Lipid Res. 54, 496–502 (2013).Article
CAS
PubMed
PubMed Central
Google Scholar
Kimura, Y. et al. Microanalysis for MDR1 ATPase by high-performance liquid chromatography with a titanium dioxide column. Anal. Biochem. 326, 262–266 (2004).Article
CAS
PubMed
Google Scholar
Trott, O. & Olson, A. J. AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. J. Comput. Chem. 31, 455–461 (2010).Article
CAS
PubMed
PubMed Central
Google Scholar
Coutsias, E. A., Seok, C., Jacobson, M. P. & Dill, K. A. A kinematic view of loop closure. J. Comput. Chem. 25, 510–528 (2004).Article
CAS
PubMed
Google Scholar
Jorgensen, C., Ulmschneider, M. B. & Searson, P. C. Modeling substrate entry into the P-glycoprotein efflux pump at the blood-brain barrier. J. Med. Chem. 66, 16615–16627 (2023).Article
CAS
PubMed
Google Scholar
Domicevica, L., Koldso, H. & Biggin, P. C. Multiscale molecular dynamics simulations of lipid interactions with P-glycoprotein in a complex membrane. J. Mol. Graph Model 80, 147–156 (2018).Article
CAS
PubMed
Google Scholar
Lee, J. et al. CHARMM-GUI membrane builder for complex biological membrane simulations with glycolipids and lipoglycans. J. Chem. Theory Comput. 15, 775–786 (2019).Article
CAS
PubMed
Google Scholar
Jo, S., Kim, T., Iyer, V. G. & Im, W. CHARMM-GUI: a web-based graphical user interface for CHARMM. J. Comput. Chem. 29, 1859–1865 (2008).Article
CAS
PubMed
Google Scholar
Lomize, M. A., Pogozheva, I. D., Joo, H., Mosberg, H. I. & Lomize, A. L. OPM database and PPM web server: resources for positioning of proteins in membranes. Nucleic Acids Res 40, D370–D376 (2012).Article
CAS
PubMed
Google Scholar
Abraham, M. J. et al. GROMACS: High performance molecular simulations through multi-level parallelism from laptops to supercomputers. SoftwareX 1–2, 19–25 (2015).Article
Google Scholar
Huang, J. et al. CHARMM36m: an improved force field for folded and intrinsically disordered proteins. Nat. Methods 14, 71–73 (2017).Article
CAS
PubMed
Google Scholar
Klauda, J. B. et al. Update of the CHARMM all-atom additive force field for lipids: validation on six lipid types. J. Phys. Chem. B 114, 7830–7843 (2010).Article
CAS
PubMed
PubMed Central
Google Scholar
Vanommeslaeghe, K. et al. CHARMM general force field: A force field for drug-like molecules compatible with the CHARMM all-atom additive biological force fields. J. Comput. Chem. 31, 671–690 (2010).Article
CAS
PubMed
PubMed Central
Google Scholar
Kim, S. et al. CHARMM-GUI ligand reader and modeler for CHARMM force field generation of small molecules. J. Comput. Chem. 38, 1879–1886 (2017).Article
CAS
PubMed
PubMed Central
Google Scholar
Parrinello, M. & Rahman, A. Polymorphic transitions in single crystals: a new molecular dynamics method. J. Appl Phys. 52, 7182–7190 (1981).Article
CAS
Google Scholar
Hoover, W. G. Canonical dynamics: equilibrium phase-space distributions. Phys. Rev. A Gen. Phys. 31, 1695–1697 (1985).Article
CAS
PubMed
Google Scholar
Kumari, R. & Kumar, R. Open Source Drug Discovery C., Lynn A. g_mmpbsa–a GROMACS tool for high-throughput MM-PBSA calculations. J. Chem. Inf. Model 54, 1951–1962 (2014).Article
CAS
PubMed
Google Scholar
Humphrey, W., Dalke, A. & Schulten, K. VMD: visual molecular dynamics. J. Mol. Graph 14, 33–38 (1996).Article
CAS
PubMed
Google Scholar
Laskowski, R. A. & Swindells, M. B. LigPlot+: multiple ligand-protein interaction diagrams for drug discovery. J. Chem. Inf. Model 51, 2778–2786 (2011).Article
CAS
PubMed
Google Scholar