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Predicting transcriptional responses to novel chemical perturbations using deep generative model for drug discovery

PRnet: perturbation-conditioned deep generative model for transcriptional response predictionIn this paper, we formulate the transcriptional response prediction as a distribution generation problem conditioned on perturbations. Cells inherently...

Virtual resection evaluation based on sEEG propagation network for drug-resistant epilepsy

PatientsWe used two datasets: (1) Clinical data with 6 patients with 12 seizures from the neurosurgery department of Shanxi Provincial People’s Hospital; (2) HUP data with 10...

Differential amino acid usage leads to ubiquitous edge effect in proteomes across domains of life that can be explained by amino acid secondary structure...

Proteomes differ among distant domains of lifeTwo competing hypotheses suggest that amino acid usage in proteomes differ or not among distant groups of living organisms. The lineage-specific...

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BEROLECMI: a novel prediction method to infer circRNA-miRNA interaction from the role definition of molecular attributes and biological networks | BMC Bioinformatics

Evaluation criteriaIn this study, we introduce five-fold cross-validation (five-fold CV) to evaluate the performance of the proposed method. five-fold CV divides the CMI data...

‘Lord, make them die an awful death’: Prisoner’s dark pleas found etched into Roman-era prison

An archaeologist in Corinth, Greece, has identified the remains of a Roman prison — one of the few prisons identified from the Roman world.Historical...

Acoustically shaped DNA-programmable materials | Nature Communications

Our experimental system includes two complementary DNA octahedral origami frames with about 30 nm edge length that can self-assemble into crystalline organization with a cubic...

Cannabis use linked to head and neck cancer risk

Using cannabis heavily and regularly may raise the risk of head and neck cancers, a new study finds.The research looked at 20 years' worth...

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