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Design of new α-glucosidase inhibitors based on the bis-4-hydroxycoumarin skeleton: Synthesis, evaluation, and in silico studies

ChemistryThe synthetic route for the synthesis of bis-4-hydroxycoumarin-phenoxy-1,2,3-triazole-N-phenylacetamide derivatives 5a-m has been depicted in Scheme 1. Firstly, a mixture of 3-methoxy-4-(prop-2-yn-1-yloxy)benzaldehyde 1 and 4-hydroxycoumarin...

Forest restoration can boost people, nature and climate simultaneously

Forest restoration can benefit humans, boost biodiversity and help tackle climate change simultaneously, new research suggests. Restoring forests is often seen in terms of "trade-offs"...

Rp3 – Ribosome profiling-assisted proteogenomics improves coverage and confidence in Ribo-Seq

Scientists have long believed that the human genome—the complete set of DNA in our bodies—contained a relatively fixed number of genes, each coding for...

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