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The GIAB genomic stratifications resource for human reference genomes

The GIAB stratification resource is a publicly available dataset for the human reference genome. Here we describe the extension of this resource to the CHM13 reference genome...

Graph attention automatic encoder based on contrastive learning for domain recognition of spatial transcriptomics

With the aim of fully utilizing the available information for spatial domain recognition, we propose a deep learning-based method named GAAEST, which aims to uncover the hidden...

Identification of brain region-specific landscape and functions of clustered circRNAs in Alzheimer’s disease using circMeta2

A robust and comprehensive computational framework for circRNA cluster DE analysisMore than 50% of circRNAs are clustered due to alternative back splicing (ABS), forming groups of circRNAs...

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Building a learnable universal coordinate system for single-cell atlas with a joint-VAE model

Overview of UniCoordWe developed UniCoord to learn key features that represent cellular heterogeneities from scRNA-seq data. We devised a specially tuned joint-VAE model to...

In breakthrough Alzheimer’s discovery, research team finds new targets and biomarkers for potential novel therapies

New findings out of Emory University are challenging existing theories about the origins of Alzheimer's, the leading cause of dementia in the elderly worldwide....

My favorite smartwatch I tested this year is now at its lowest-ever price

A higher price does not mean better quality — it is the first lesson you learn when you go through as many fitness trackers...

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