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Comprehensive evaluation and prediction of editing outcomes for near-PAMless adenine and cytosine base editors

Generation of near-PAMless base editorsTo leverage the expanded PAM compatibility offered by SpRY, our study utilized the BE4max-SpRY and ABEmax-SpRY, which incorporate SpRY in place of SpCas9,...

Self-supervised learning for accurately modelling hierarchical evolutionary patterns of cerebrovasculature

FrameworkThe proposed pipeline for hierarchical quantitative analysis of cerebrovasculature is illustrated in Fig. 1. Paired T1 and TOF-MRA images were acquired from each subject. TOF-MRA volumes were utilized...

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COMSE – analysis of single-cell RNA-seq data using community detection-based feature selection

Single-cell RNA sequencing (scRNA-seq) is a powerful technique that allows scientists to study individual cells in detail. This method is particularly useful because it...

Rare diseases point to connections between metabolism and immunity

Inherited diseases of metabolism and immunity have more in common than previously recognized, according to a new study published in the journal Science Immunology....

Ancient DNA reveals Indigenous dog lineages found at Jamestown, Virginia

Previous scientific studies have indicated that North American dog lineages were replaced with European ones between 1492 and the present day. To better understand...

The bee’s knees: New tests created to find fake honey

Researchers led by Cranfield University have developed new ways to detect sugar syrup adulteration in honey, paving the way for fast and accurate tests...

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