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Self-supervised learning for accurately modelling hierarchical evolutionary patterns of cerebrovasculature

FrameworkThe proposed pipeline for hierarchical quantitative analysis of cerebrovasculature is illustrated in Fig. 1. Paired T1 and TOF-MRA images were acquired from each subject. TOF-MRA volumes were utilized...

Comprehensive evaluation and prediction of editing outcomes for near-PAMless adenine and cytosine base editors

Generation of near-PAMless base editorsTo leverage the expanded PAM compatibility offered by SpRY, our study utilized the BE4max-SpRY and ABEmax-SpRY, which incorporate SpRY in place of SpCas9,...

The prominent pervasive oncogenic role and tissue specific permissiveness of RAS gene mutations

Data mining of CRISPR effect scores in DepMap showed prevalent difference in RAS genes between mutant lines vs. WT lines but also revealed drawbacks of individual assessment...

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Scale Bio launches ‘100 Million Cell Challenge’ in Collaboration with Ultima Genomics and NVIDIA

Scale Biosciences (Scale Bio), a leader in innovative and scalable single cell analysis solutions, today announced the launch of the “100 Million Cell Challenge,”...

Novel sulfonic groups grafted sugarcane bagasse biosorbent for efficient removal of cationic dyes from wastewater

CharacterizationsSEM and TEMThe surface morphology of the modified SCB (SCB@SA) was detected by employing the SEM, as seen in Fig. 2. At low magnification, the...

Researchers use snRNA-seq to identify malignant cells responsible for relapse in neuroblastoma

Grossmann LD, Chen CH, Uzun Y, Thadi A, Wolpaw AJ, Louault K, Goldstein Y, Surrey LF, Martinez D, Calafatti M, Gerelus M, Gao P,...

Scientists discover superbug’s rapid path to antibiotic resistance

Scientists have discovered how the hospital superbug C.diff rapidly evolves resistance to the frontline drug used for treatment in the UK. Clostridioides difficile (C. diff),...

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