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Comprehensive evaluation and prediction of editing outcomes for near-PAMless adenine and cytosine base editors

Generation of near-PAMless base editorsTo leverage the expanded PAM compatibility offered by SpRY, our study utilized the BE4max-SpRY and ABEmax-SpRY, which incorporate SpRY in place of SpCas9,...

Self-supervised learning for accurately modelling hierarchical evolutionary patterns of cerebrovasculature

FrameworkThe proposed pipeline for hierarchical quantitative analysis of cerebrovasculature is illustrated in Fig. 1. Paired T1 and TOF-MRA images were acquired from each subject. TOF-MRA volumes were utilized...

The landscape of RNA binding proteins in mammalian spermatogenesis | Science

Despite continuous expansion of the RNA binding protein (RBP) world, there is a lack of systematic understanding of RBPs in the mammalian testis, which harbors one of...

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Das Oktoberfest—viel Bierzeltdunst und Methan

This is an authorized translation of an Eos article. Dies ist eine autorisierte Übersetzung eines Eos artikels. Millionen von Menschen besuchen große Feste wie den Karneval in Rio de...

Playing Lego with Gauge Fields: Stacking Spin Liquid Layers

The standard model of particle physics, the most successful description of our universe is...

Planet Labs images of the 30 July 2024 Wayanad landslide in India

The Landslide Blog is written by Dave Petley, who is widely recognized as a world leader in the study and management of landslides. Recovery...

At the Salton Sea, Uncovering the Culprit of Lung Disease

At the Salton Sea, Uncovering the Culprit of Lung Disease We use cookies to ensure that we give you the best...

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