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HMGA1 orchestrates chromatin compartmentalization and sequesters genes into 3D networks coordinating senescence heterogeneity

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HMGA1 modulates cellular functionality by affecting both up- and down-regulated genes in OISTo characterise HMGA1-dependent gene regulation, we utilized the oncogenic RAS-induced senescence (OIS)...

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A plant virus differentially alters DNA methylation in two cryptic species of a hemipteran vector

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Bewick, A. J., Vogel, K. J., Moore, A. J. & Schmitz, R. J. Evolution of DNA methylation across insects. Mol. Biol. Evol. 34, 654–665...

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Diversity and specificity of molecular functions in cyanobacterial symbionts

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Demoulin, C. F. et al. Cyanobacteria evolution: Insight from the fossil record. Free Radic. Biol. Med. 140, 206–223 (2019).Article CAS ...

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Design of new α-glucosidase inhibitors based on the bis-4-hydroxycoumarin skeleton: Synthesis, evaluation, and in silico studies

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ChemistryThe synthetic route for the synthesis of bis-4-hydroxycoumarin-phenoxy-1,2,3-triazole-N-phenylacetamide derivatives 5a-m has been depicted in Scheme 1. Firstly, a mixture of 3-methoxy-4-(prop-2-yn-1-yloxy)benzaldehyde 1 and 4-hydroxycoumarin...

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Rp3 – Ribosome profiling-assisted proteogenomics improves coverage and confidence in Ribo-Seq

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Scientists have long believed that the human genome—the complete set of DNA in our bodies—contained a relatively fixed number of genes, each coding for...

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Multi-omics analysis uncovers the transcriptional regulatory mechanism of magnesium Ions in the synthesis of active ingredients in Sophora tonkinensis

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