HMGA1 modulates cellular functionality by affecting both up- and down-regulated genes in OISTo characterise HMGA1-dependent gene regulation, we utilized the oncogenic RAS-induced senescence (OIS)...
ChemistryThe synthetic route for the synthesis of bis-4-hydroxycoumarin-phenoxy-1,2,3-triazole-N-phenylacetamide derivatives 5a-m has been depicted in Scheme 1. Firstly, a mixture of 3-methoxy-4-(prop-2-yn-1-yloxy)benzaldehyde 1 and 4-hydroxycoumarin...
Scientists have long believed that the human genome—the complete set of DNA in our bodies—contained a relatively fixed number of genes, each coding for...