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Comprehensive evaluation and prediction of editing outcomes for near-PAMless adenine and cytosine base editors

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Generation of near-PAMless base editorsTo leverage the expanded PAM compatibility offered by SpRY, our study utilized the BE4max-SpRY and ABEmax-SpRY, which incorporate SpRY in place of SpCas9,...
HEALTHY

Will AI’s huge energy demands spur a nuclear renaissance?

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HEALTHY

Self-supervised learning for accurately modelling hierarchical evolutionary patterns of cerebrovasculature

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FrameworkThe proposed pipeline for hierarchical quantitative analysis of cerebrovasculature is illustrated in Fig. 1. Paired T1 and TOF-MRA images were acquired from each subject. TOF-MRA volumes were utilized...
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Ask us anything: what breakthrough in ecological theory could have the biggest impact for applied conservation?

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Recently we invited you to ask us anything. Today’s question comes from Falko Buschke, who asks (paraphrasing) “What breakthrough in ecological theory could have...
FITNESS MATTERS

Enhanced circularly polarized luminescence attained via self-assembly of heterochiral as opposed to homochiral dipeptides in water

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Circularly polarized luminescence (CPL) is gaining interest across various disciplines, including materials...
WOLDING

Dying to organise | Research Communities by Springer Nature

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Death and birth in cytoskeleton organisation Cells rely on the cytoskeleton, a dynamic collection of...
COACHING

How complex life arose under extreme stress

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There’s one thing plants and humans have in common – both are made up of single...
BIOCHEMICAL

Oyster shells repurposed as magic ‘Seawool’

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