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Shrinkage estimation of gene interaction networks in single-cell RNA sequencing data | BMC Bioinformatics

OverviewGraphical models are graphs in which nodes are random variables and the presence of edges represent conditional dependence or “direct links” between them . Two random variables,...

Predicting transcriptional responses to novel chemical perturbations using deep generative model for drug discovery

PRnet: perturbation-conditioned deep generative model for transcriptional response predictionIn this paper, we formulate the transcriptional response prediction as a distribution generation problem conditioned on perturbations. Cells inherently...

KiNext: a portable and scalable workflow for the identification and classification of protein kinases | BMC Bioinformatics

The KiNext pipeline consists of 7 processes for kinome identification and protein kinase classification followed by phylogenetic analysis of the recovered kinases (Fig. 1).Fig. 1Overview of the 7 processes...

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Hidden Threat: Mycoplasma genitalium Infection in Pregnancy Linked to Lower Birth Weight Babies

Sexually transmitted infections (STIs) and bacterial vaginosis (BV) are common infections that cause a...

Single-nuclei RNA sequencing identifies racial differences in rare endometrial cancer

Northwestern Medicine investigators have discovered that uterine serous carcinoma tumors in Black patients express more aggressive and immunosuppressive features than tumors in white patients,...

Action plan to help patients with lung disease cope with wildfire smoke

A multidisciplinary team of UC Davis Health experts are calling on health systems to create wildfire preparedness action plans to support patients with preexisting...

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