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Mechanism of PCNA loading by Ctf18-RFC for leading-strand DNA synthesis | Science

1 August 2024

The proliferating cell nuclear antigen (PCNA) clamp encircles DNA to hold DNA polymerases (Pols) to DNA for processivity. The Ctf18-RFC PCNA loader, a replication factor C (RFC) variant, is specific to the leading-strand Pol (Polε). We reveal here the …

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Zero-shot transfer of protein sequence likelihood models to thermostability prediction

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Zero-shot transfer of protein sequence likelihood models to thermostability prediction

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