A robust heterogeneous chiral phosphoric acid enables multi decagram scale production of optically active N,S-ketals

Green Chem., 2024, 26,4593-4599DOI: 10.1039/D4GC00019F, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Aitor Maestro, Bhanwar K. Malviya, Gerald Auer, Sándor B. Ötvös, C. Oliver KappeA multi-decagram scale synthesis of enantioenriched N,S-ketals was achieved by using a robust heterogeneous organocatalyst. A new reactor design was crucial to enable the scaling up of this reaction while the overall catalyst loading below 0.1%.The content of this RSS Feed (c) The Royal Society of Chemistry