Thiophene-fused γ-lactams inhibit the SARS-CoV-2 main protease via reversible covalent acylation

Chem. Sci., 2024, Accepted ManuscriptDOI: 10.1039/D4SC01027B, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Gayatri Gayatri, Lennart Brewitz, Lewis Ibbotson, Eidarus Saleh, Shyam Basak, Hani Choudhry, Christopher J SchofieldEnzyme inhibitors working by O-acylation of nucleophilic serine residues are of immense medicinal importance, as exemplified by the β-lactam antibiotics. By contrast, inhibition of nucleophilic cysteine enzymes by S-acylation has…The content of this RSS Feed (c) The Royal Society of Chemistry