Lewis acid catalyzed [4+2] annulation of bicyclobutanes with dienol ethers for the synthesis of bicyclo[4.1.1]octanes

Chem. Sci., 2024, 15,10823-10829DOI: 10.1039/D4SC02767A, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Stefano Nicolai, Jérôme WaserBicyclo[4.1.1]octanes (BCOs) were synthesized in up to quantitative yields through the formal [4+2] cycloaddition of aryl and alkyl bicyclobutane (BCB) ketones with dienol silyl ethers using Al(OTf)3 as a Lewis acid catalyst.The content of this RSS Feed (c) The Royal Society of Chemistry