We herein report a waste-minimized process for the synthesis of iodinated hexa-aryl borazines in different iodination patterns and amounts. Access to these widely promising B–N-containing materials features several synthetic challenges including low solubility, narrow stability/reactivity, and limited selectivity. Therefore, the development of synthetic procedures also faces evident sustainability challenges. We have tackled these aspects by merging unconventional activation techniques with metrics-oriented synthetic design. Herein, we report a protocol that enables a fast access route to iodinated borazines which are useful substrates to access different post-functionalized more complex materials. The protocol uses simple and benign chemicals, is waste minimized (E-factor 2.79), and produces iodinated hexa-aryl borazines in good to excellent yields. An evaluation of green metrics, including EcoScale, is provided to quantify the advantages associated with the newly defined protocol.
This article is Open Access
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