Thiadiazole and selenadiazole derivatives are significant organic backbones widely utilized in drugs, bioactive molecules, and functional materials. A green and efficient one-pot synthetic methodology has been developed for the fabrication of thiadiazole/selenadiazole derivatives, which involves photocatalytic induced iodine substitution, oxydic aldehyde formation, and nucleophilic addition, resulting in C–S bond formation and hydrazylation, cyclization, and rearrangement, as well as dehydration. The present method includes good functional group tolerance, simple, mild, metal-free, and safe conditions that are in line with the principles of green chemistry, making this protocol an attractive strategy for the synthesis of bioactive molecules with thiadiazole/selenadiazole frameworks. Gratifyingly, the complanate and conjugate structures of the synthesized compounds ensured attractive fluorescent properties for successful application in biological cell imaging.
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