Quantifying Siglec-sialylated ligand interactions: a versatile 19F-T2 CPMG filtered competitive NMR displacement assay

Chem. Sci., 2024, 15,10612-10624DOI: 10.1039/D4SC01723D, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Unai Atxabal, Andrea Fernández, Maria Jesús Moure, Klaudia Sobczak, Corwin Nycholat, Verónica Almeida-Marrero, Iker Oyenarte, James C. Paulson, Andrés de la Escosura, Tomás Torres, Niels C. Reichardt, Jesús Jiménez-Barbero, June Ereño-OrbeaSialic-acid-binding immunoglobulin-like lectins (Siglecs) are integral cell surface proteins crucial for the regulation of immune responses and the maintenance of immune tolerance through interactions with sialic acids.The content of this RSS Feed (c) The Royal Society of Chemistry