Impact of arterial system alterations due to amputation on arterial stiffness and hemodynamics: a numerical study

Hrubec, Z. & Ryder, R. A. Traumatic limb amputations and subsequent mortality from cardiovascular disease and other causes. J. Chronic Dis. 33 (4), 239–250 (1980).Article 
CAS 
PubMed 

Google Scholar 
Modan, M. et al. Increased cardiovascular disease mortality rates in traumatic lower limb amputees. Am. J. Cardiol. 82 (10), 1242–1247 (1998).Article 
CAS 
PubMed 

Google Scholar 
Vollmar, J. F., Paes, E., Pauschinger, P., Henze, E. & Friesch, A. Aortic aneurysms as late sequelae of above-knee amputation. Lancet Lond. Engl. 2 (8667), 834–835 (1989).Article 
CAS 

Google Scholar 
Yekutiel, M., Brooks, M. E., Ohry, A., Yarom, J. & Carel, R. The prevalence of hypertension, ischaemic heart disease and diabetes in traumatic spinal cord injured patients and amputees. Paraplegia. 27 (1), 58–62 (1989).CAS 
PubMed 

Google Scholar 
Nystoriak, M. A. & Bhatnagar, A. Cardiovascular effects and benefits of exercise. Front. Cardiovasc. Med. 5, 135 (2018).Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 
Naschitz, J. E. & Lenger, R. Why traumatic leg amputees are at increased risk for cardiovascular diseases. QJM Mon J. Assoc. Physicians. 101 (4), 251–259 (2008).Article 
CAS 

Google Scholar 
Laurent, S. et al. Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients. Hypertension. 37 (5), 1236–1241 (2001).Article 
CAS 
PubMed 

Google Scholar 
Ben-Shlomo, Y. et al. Aortic pulse wave velocity improves cardiovascular event prediction: an individual participant meta-analysis of prospective observational data from 17,635 subjects. J. Am. Coll. Cardiol. 63 (7), 636–646 (2014).Article 
PubMed 

Google Scholar 
Zoungas, S. & Asmar, R. P. Arterial stiffness and cardiovascular outcome. Clin. Exp. Pharmacol. Physiol. 34 (7), 647–651 (2007).Article 
CAS 
PubMed 

Google Scholar 
Vlachopoulos, C., Aznaouridis, K. & Stefanadis, C. Prediction of cardiovascular events and all-cause mortality with arterial stiffness: a systematic review and meta-analysis. J. Am. Coll. Cardiol. 55 (13), 1318–1327 (2010).Article 
PubMed 

Google Scholar 
Mendes-Pinto, D., Rodrigues-Machado, M., da Avelar, G., Navarro, G. L. & Dardik, T. P. Arterial stiffness predicts amputation and death in patients with chronic limb-threatening ischemia. J. Vasc Surg. 74 (6), 2014–2022e4 (2021).Article 
PubMed 

Google Scholar 
Wei, J. et al. [Effect of lower limb amputation level on aortic hemodynamics: a numerical study]. Sheng Wu Yi Xue Gong. Cheng Xue Za Zhi J. Biomed. Eng. Shengwu Yixue Gongchengxue Zazhi. 39 (1), 67–74 (2022).
Google Scholar 
Li, X. et al. Effect of lower extremity amputation on cardiovascular hemodynamic environment: an in vitro study. J. Biomech. 145, 111368 (2022).Article 
PubMed 

Google Scholar 
Bleasdale, R. A., Parker, K. H. & Jones, C. J. H. Chasing the wave. Unfashionable but important new concepts in arterial wave travel. Am. J. Physiol-Heart Circ. Physiol. 284 (6), H1879–H1885 (2003).Article 
CAS 
PubMed 

Google Scholar 
Parker, K. H. & Jones, C. J. Forward and backward running waves in the arteries: analysis using the method of characteristics. J. Biomech. Eng. 112 (3), 322–326 (1990).Article 
CAS 
PubMed 

Google Scholar 
Khir, A. W., O’Brien, A., Gibbs, J. S. & Parker, K. H. Determination of wave speed and wave separation in the arteries. J. Biomech. 34 (9), 1145–1155 (2001).Article 
CAS 
PubMed 

Google Scholar 
Reymond, P., Merenda, F., Perren, F., Rüfenacht, D. & Stergiopulos, N. Validation of a one-dimensional model of the systemic arterial tree. Am. J. Physiol. Heart Circ. Physiol. 297 (1), H208–222 (2009).Article 
CAS 
PubMed 

Google Scholar 
Segers, P., Stergiopulos, N., Verdonck, P. & Verhoeven, R. Assessment of distributed arterial network models. Med. Biol. Eng. Comput. 35 (6), 729–736 (1997).Article 
CAS 
PubMed 

Google Scholar 
Langewouters, G. J., Wesseling, K. H. & Goedhard, W. J. The static elastic properties of 45 human thoracic and 20 abdominal aortas in vitro and the parameters of a new model. J. Biomech. 17 (6), 425–435 (1984).Article 
CAS 
PubMed 

Google Scholar 
Holenstein, R., Niederer, P. & Anliker, M. A viscoelastic model for use in predicting arterial pulse waves. J. Biomech. Eng. 102 (4), 318–325 (1980).Article 
CAS 
PubMed 

Google Scholar 
Stergiopulos, N., Young, D. F. & Rogge, T. R. Computer simulation of arterial flow with applications to arterial and aortic stenoses. J. Biomech. 25 (12), 1477–1488 (1992).Article 
CAS 
PubMed 

Google Scholar 
Guan, D., Liang, F. & Gremaud, P. A. Comparison of the Windkessel model and structured-tree model applied to prescribe outflow boundary conditions for a one-dimensional arterial tree model. J. Biomech. 49 (9), 1583–1592 (2016).Article 
PubMed 

Google Scholar 
Reymond, P., Bohraus, Y., Perren, F., Lazeyras, F. & Stergiopulos, N. Validation of a patient-specific one-dimensional model of the systemic arterial tree. Am. J. Physiol. Heart Circ. Physiol. 301 (3), H1173–1182 (2011).Article 
CAS 
PubMed 

Google Scholar 
Obeid, H. et al. Numerical assessment and comparison of pulse wave velocity methods aiming at measuring aortic stiffness. Physiol. Meas. 38 (11), 1953–1967 (2017).Article 
PubMed 

Google Scholar 
Sagawa, K., Suga, H., Shoukas, A. A. & Bakalar, K. M. End-systolic pressure/volume ratio: a new index of ventricular contractility. Am. J. Cardiol. 40 (5), 748–753 (1977).Article 
CAS 
PubMed 

Google Scholar 
Fortier, C. & Agharazii, M. Arterial stiffness gradient. Pulse Basel Switz. 3 (3–4), 159–166 (2016).
Google Scholar 
Obeid, H. et al. Radial-digital pulse wave velocity: a non-invasive method for assessing stiffness of small conduit arteries. Am. J. Physiol. Heart Circ. Physiol. 320, H1361–H1369 (2021).Westerhof, N., Stergiopulos, N. & Noble, M. I. M. Snapshots of Hemodynamics: An Aid for Clinical Research and Graduate Education 2nd edn XIV, 272 (Springer, 2010).Nichols, W. W., O’Rourke, M. F. & Vlachopoulos, C. McDonald’s Blood flow in Arteries. Sixth (Arnold, 2011).Gaddum, N. R., Alastruey, J., Beerbaum, P., Chowienczyk, P. & Schaeffter, T. A technical assessment of pulse wave velocity algorithms applied to non-invasive arterial waveforms. Ann. Biomed. Eng. 41 (12), 2617–2629 (2013).Article 
CAS 
PubMed 

Google Scholar 
Westerhof, N., Sipkema, P., van den Bos, G. C. & Elzinga, G. Forward and backward waves in the arterial system. Cardiovasc. Res. 6 (6), 648–656 (1972).Article 
CAS 
PubMed 

Google Scholar 
Parker, K. H., Jones, C. J., Dawson, J. R. & Gibson, D. G. What stops the flow of blood from the heart? Heart Vessels. 4 (4), 241–245 (1988).Article 
CAS 
PubMed 

Google Scholar 
Wang, J. J., Shrive, N. G., Parker, K. H. & Tyberg, J. V. Wave as defined by wave intensity analysis. Med. Biol. Eng. Comput. 47 (2), 189–195 (2009).Article 
PubMed 

Google Scholar 
Parker, K. H. An introduction to wave intensity analysis. Med. Biol. Eng. Comput. 47 (2), 175–188 (2009).Article 
PubMed 

Google Scholar 
Nordgaard, H. et al. Impact of competitive flow on wall shear stress in coronary surgery: computational fluid dynamics of a LIMA–LAD model. Cardiovasc. Res. 88 (3), 512–519 (2010).Article 
CAS 
PubMed 

Google Scholar 
Malek, A. M., Alper, S. L. & Izumo, S. Hemodynamic shear stress and its role in atherosclerosis. JAMA. 282 (21), 2035–2042 (1999).Article 
CAS 
PubMed 

Google Scholar 
Murray, A. M., Gaffney, B. M., Davidson, B. S. & Christiansen, C. L. Biomechanical compensations of the trunk and lower extremities during stepping tasks after unilateral Transtibial Amputation. Clin. Biomech. Bristol Avon. 49, 64–71 (2017).Article 
PubMed 

Google Scholar 
Abola, M. T. B. et al. Fate of individuals with ischemic amputations in the REACH Registry: three-year cardiovascular and limb-related outcomes. Atherosclerosis. 221 (2), 527–535 (2012).Article 
CAS 
PubMed 

Google Scholar 
Fortington, L. V. et al. Short and long term mortality rates after a lower limb amputation. Eur. J. Vasc Endovasc Surg. 46 (1), 124–131 (2013).Article 
CAS 
PubMed 

Google Scholar 
Paes, E. et al. Hemodynamic and pathomorphologic changes of the aorto-iliac arteries following unilateral above knee amputation. In: (ed Liepsch, D. W.) Biofluid Mechanics. Berlin, Heidelberg: Springer; 159–165. (1990).Chapter 

Google Scholar 
Rosengren, A. et al. Association of psychosocial risk factors with risk of acute myocardial infarction in 11119 cases and 13648 controls from 52 countries (the INTERHEART study): case-control study. Lancet Lond. Engl. 364 (9438), 953–962 (2004).Article 

Google Scholar 
Boscarino, J. A. Posttraumatic stress disorder and mortality among U.S. Army veterans 30 years after military service. Ann. Epidemiol. 16 (4), 248–256 (2006).Article 
PubMed 

Google Scholar 
Kang, H. K., Bullman, T. A. & Taylor, J. W. Risk of selected cardiovascular diseases and posttraumatic stress disorder among former World War II prisoners of war. Ann. Epidemiol. 16 (5), 381–386 (2006).Article 
PubMed 

Google Scholar 
Ephraim, P. L., MacKenzie, E. J., Wegener, S. T., Dillingham, T. R. & Pezzin, L. E. Environmental barriers experienced by amputees: the Craig Hospital Inventory of environmental factors-short form. Arch. Phys. Med. Rehabil. 87 (3), 328–333 (2006).Article 
PubMed 

Google Scholar 
Boutouyrie, P., Chowienczyk, P., Humphrey, J. D. & Mitchell, G. F. Arterial stiffness and cardiovascular risk in hypertension. Circ. Res. 128 (7), 864–886 (2021).Article 
CAS 
PubMed 

Google Scholar 
Magalhães, P., Capingana, D. P., Silva, A. B. T., Capunge, I. R. & Gonçalves, M. A. A. Arterial stiffness in lower limb amputees. Clin. Med. Insights Circ. Respir Pulm Med. 5, 49–56 (2011).Article 
PubMed 
PubMed Central 

Google Scholar 
Paula-Ribeiro, M., Garcia, M. M. N., Martinez, D. G., Lima, J. R. P. & Laterza, M. C. Increased peripheral vascular resistance in male patients with traumatic lower limb amputation: one piece of the cardiovascular risk puzzle. Blood Press. Monit. 20 (6), 341–345 (2015).Article 
PubMed 

Google Scholar 
McEniery, C. M., Cockcroft, J. R., Roman, M. J., Franklin, S. S. & Wilkinson, I. B. Central blood pressure: current evidence and clinical importance. Eur. Heart J. 35 (26), 1719–1725 (2014).Article 
PubMed 
PubMed Central 

Google Scholar 
Latham, R. D. et al. Regional wave travel and reflections along the human aorta: a study with six simultaneous micromanometric pressures. Circulation. 72 (6), 1257–1269 (1985).Article 
CAS 
PubMed 

Google Scholar 
Zhou, M. et al. Wall shear stress and its role in atherosclerosis. Front. Cardiovasc. Med. 10, 1083547 (2023).Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

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