Targeting GLI1 and BAX by nanonoscapine could impede prostate adenocarcinoma progression

Rawla, P. Epidemiology of prostate cancer. World J. Oncol. 10(2), 63–89 (2019).Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 
Siegel, R. L., Miller, K. D. & Jemal, A. Cancer statistics, 2020. CA Cancer J. Clin. 70(1), 7–30 (2020).Article 
PubMed 

Google Scholar 
Gann, P. H. Risk factors for prostate cancer. Rev. Urol. 4(Suppl 5), S3–S10 (2002).PubMed 
PubMed Central 

Google Scholar 
Grozescu, T. & Popa, F. Prostate cancer between prognosis and adequate/proper therapy. J. Med. Life 10(1), 5–12 (2017).CAS 
PubMed 
PubMed Central 

Google Scholar 
Sathianathen, N. J. et al. Landmarks in prostate cancer. Nat. Rev. Urol. 15(10), 627–642 (2018).Article 
PubMed 

Google Scholar 
Di Minno, A. et al. 8-hydroxy-2-deoxyguanosine and 8-iso-prostaglandin F2α: putative biomarkers to assess oxidative stress damage following robot-assisted radical prostatectomy (RARP). J. Clin. Med. 11(20), 6102 (2022).Article 
PubMed 
PubMed Central 

Google Scholar 
Siddiqui, Z. A. & Krauss, D. J. Adjuvant androgen deprivation therapy for prostate cancer treated with radiation therapy. Transl. Androl. Urol. 7(3), 378–389 (2018).Article 
PubMed 
PubMed Central 

Google Scholar 
Perlmutter, M. A. & Lepor, H. Androgen deprivation therapy in the treatment of advanced prostate cancer. Rev. Urol. 9(Suppl 1), S3-8 (2007).PubMed 
PubMed Central 

Google Scholar 
Sandhu, S. et al. Prostate cancer. Lancet 398(10305), 1075–1090 (2021).Article 
CAS 
PubMed 

Google Scholar 
Sekhoacha, M. et al. Prostate cancer review: genetics, diagnosis, treatment options, and alternative approaches. Molecules 27(17), 5730 (2022).Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 
Rida, P. C. et al. The noscapine chronicle: a pharmaco-historic biography of the opiate alkaloid family and its clinical applications. Med. Res. Rev. 35(5), 1072–1096 (2015).Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 
Chen, X., Dang, T. T. & Facchini, P. J. Noscapine comes of age. Phytochemistry 111, 7–13 (2015).Article 
CAS 
PubMed 

Google Scholar 
Zhou, J. et al. Minor alteration of microtubule dynamics causes loss of tension across kinetochore pairs and activates the spindle checkpoint. J. Biol. Chem. 277(19), 17200–17208 (2002).Article 
CAS 
PubMed 

Google Scholar 
Barken, I., Geller, J. & Rogosnitzky, M. Noscapine inhibits human prostate cancer progression and metastasis in a mouse model. Anticancer Res. 28(6A), 3701–3704 (2008).CAS 
PubMed 

Google Scholar 
Lasagna, L., Owens, A. H. Jr., Shnider, B. I. & Gold, G. L. Toxicity after large doses of noscapine. Cancer Chemother. Rep. 15, 33–34 (1961).CAS 
PubMed 

Google Scholar 
Ohlsson, S. et al. Noscapine may increase the effect of warfarin. Br. J. Clin. Pharmacol. 65(2), 277–278 (2008).Article 
CAS 
PubMed 

Google Scholar 
Madan, J. et al. Sterically stabilized gelatin microassemblies of noscapine enhance cytotoxicity, apoptosis and drug delivery in lung cancer cells. Colloids Surf. B Biointerfaces 107, 235–244 (2013).Article 
CAS 
PubMed 

Google Scholar 
Ma, Y. et al. Small molecule nanodrugs for cancer therapy. Mater. Today Chem. 4, 26–39 (2017).Article 
ADS 

Google Scholar 
Mahmoudian, M. & Rahimi-Moghaddam, P. The anti-cancer activity of noscapine: a review. Recent Pat Anticancer Drug Discov. 4(1), 92–97 (2009).Article 
CAS 
PubMed 

Google Scholar 
Mahindroo, N., Punchihewa, C. & Fujii, N. Hedgehog-Gli signaling pathway inhibitors as anticancer agents. J. Med. Chem. 52(13), 3829–3845 (2009).Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 
Chen, R. & Overholtzer, M. When BAX doesn’t kill. Cell Cycle 17(4), 412–413 (2018).Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 
Hong, M. et al. RNA sequencing: new technologies and applications in cancer research. J. Hematol. Oncol. 13(1), 166 (2020).Article 
PubMed 
PubMed Central 

Google Scholar 
Ji, F. & Sadreyev, R. I. RNA-seq: basic bioinformatics analysis. Curr. Protocols Mol. Biol. 124(1), e68–e68 (2018).Article 

Google Scholar 
Azarian, M. et al. Design and optimization of noscapine nanosuspensions and study of its cytotoxic effect. J. Biomol. Struct. Dyn. 37(1), 147–155 (2019).Article 
CAS 
PubMed 

Google Scholar 
Ali, A. & Kulik, G. Signaling pathways that control apoptosis in prostate cancer. Cancers 13(5), 937 (2021).Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 
Liu, Z. et al. Direct activation of bax protein for cancer therapy. Med. Res. Rev. 36(2), 313–341 (2016).Article 
CAS 
PubMed 

Google Scholar 
Bao, Q. & Shi, Y. Apoptosome: a platform for the activation of initiator caspases. Cell Death Diff. 14(1), 56–65 (2007).Article 
CAS 

Google Scholar 
Kocak, C., Kocak, F. A. T. M. A., Ozturk, B., Tekin, G. & Vatansev, H. Cytotoxic, anti-proliferative and apoptotic effects of noscapine on human estrogen receptor positive (MCF-7) and negative (MDA-MB-231) breast cancer cell lines. Bratisl. Lek. Listy 121, 43–50 (2020).CAS 
PubMed 

Google Scholar 
Quisbert-Valenzuela, E. O. & Calaf, G. M. Apoptotic effect of noscapine in breast cancer cell lines. Int. J. Oncol. 48(6), 2666–2674 (2016).Article 
CAS 
PubMed 

Google Scholar 
Tian, X. et al. Down-regulation of liver-intestine cadherin enhances noscapine-induced apoptosis in human colon cancer cells. Expert Rev. Anticancer Ther. 17(9), 857–863 (2017).Article 
CAS 
PubMed 

Google Scholar 
Yang, Z. R. et al. Noscapine induces mitochondria-mediated apoptosis in human colon cancer cells in vivo and in vitro. Biochem. Biophys. Res. Commun. 421(3), 627–633 (2012).Article 
CAS 
PubMed 

Google Scholar 
Xu, G. et al. Noscapine inhibits human hepatocellular carcinoma growth through inducing apoptosis in vitro and in vivo. Neoplasma 63(5), 726–733 (2016).Article 
CAS 
PubMed 

Google Scholar 
Liu, M., Luo, X. J., Liao, F., Lei, X. F. & Dong, W. G. Noscapine induces mitochondria-mediated apoptosis in gastric cancer cells in vitro and in vivo. Cancer Chemother. Pharmacol. 67, 605–612 (2011).Article 
CAS 
PubMed 

Google Scholar 
Heidari, N. et al. Apoptotic pathway induced by noscapine in human myelogenous leukemic cells. Anticancer Drugs 18(10), 1139–1147 (2007).Article 
CAS 
PubMed 

Google Scholar 
Chougule, M., Patel, A. R., Sachdeva, P., Jackson, T. & Singh, M. Anticancer activity of Noscapine, an opioid alkaloid in combination with Cisplatin in human non-small cell lung cancer. Lung Cancer 71(3), 271–282 (2011).Article 
CAS 
PubMed 

Google Scholar 
Jackson, T., Chougule, M. B., Ichite, N., Patlolla, R. R. & Singh, M. Antitumor activity of noscapine in human non-small cell lung cancer xenograft model. Cancer Chemother. Pharmacol. 63, 117–126 (2008).Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 
Qian, S. et al. The role of BCL-2 family proteins in regulating apoptosis and cancer therapy. Front Oncol. 12, 985363 (2022).Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 
Kang, R. et al. The Beclin 1 network regulates autophagy and apoptosis. Cell Death Differ. 18(4), 571–580 (2011).Article 
MathSciNet 
CAS 
PubMed 
PubMed Central 

Google Scholar 
Yun, C. W. & Lee, S. H. The roles of autophagy in cancer. Int. J. Mol. Sci. 19(11), 3466 (2018).Article 
PubMed 
PubMed Central 

Google Scholar 
Loizzo, D. et al. Novel insights into autophagy and prostate cancer: a comprehensive review. Int. J. Mol. Sci. 23(7), 3826 (2022).Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 
Slee, E. A., Keogh, S. A. & Martin, S. J. Cleavage of BID during cytotoxic drug and UV radiation-induced apoptosis occurs downstream of the point of Bcl-2 action and is catalysed by caspase-3: a potential feedback loop for amplification of apoptosis-associated mitochondrial cytochrome c release. Cell Death Differ. 7(6), 556–565 (2000).Article 
CAS 
PubMed 

Google Scholar 
Krajewska, M. et al. Expression of Bcl-2 family member Bid in normal and malignant tissues. Neoplasia 4(2), 129–140 (2002).Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 
Beurel, E. & Jope, R. S. The paradoxical pro- and anti-apoptotic actions of GSK3 in the intrinsic and extrinsic apoptosis signaling pathways. Prog. Neurobiol. 79(4), 173–189 (2006).Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 
Quinn, L. M. & Richardson, H. Bcl-2 in cell cycle regulation. Cell Cycle 3(1), 6–8 (2004).Article 

Google Scholar 
Diril, M. K. et al. Cyclin-dependent kinase 1 (Cdk1) is essential for cell division and suppression of DNA re-replication but not for liver regeneration. Proc. Nat. Acad. Sci. 109(10), 3826–3831 (2012).Article 
ADS 
CAS 
PubMed 
PubMed Central 

Google Scholar 
Liao, H., Ji, F. & Ying, S. CDK1: beyond cell cycle regulation. Aging 9(12), 2465–2466 (2017).Article 
PubMed 
PubMed Central 

Google Scholar 
Guadagno, J. et al. Microglia-derived IL-1β triggers p53-mediated cell cycle arrest and apoptosis in neural precursor cells. Cell Death Dis. 6(6), e1779–e1779 (2015).Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 
Nguyen, T. H. et al. A systematic review and meta-analyses of interleukin-1 receptor associated kinase 3 (IRAK3) action on inflammation in in vivo models for the study of sepsis. PLOS ONE 17(2), e0263968 (2022).Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 
Cui, X. et al. NF-κB suppresses apoptosis and promotes bladder cancer cell proliferation by upregulating survivin expression in vitro and in vivo. Sci. Rep. 7(1), 40723 (2017).Article 
ADS 
CAS 
PubMed 
PubMed Central 

Google Scholar 
Robbins, D. J., Fei, D. L. & Riobo, N. A. The Hedgehog signal transduction network. Sci. Signal. 5(246), re6 (2012).Article 
PubMed 
PubMed Central 

Google Scholar 
Mohler, J. Requirements for hedgehog, a segmental polarity gene, in patterning larval and adult cuticle of Drosophila. Genetics 120(4), 1061–1072 (1988).Article 
MathSciNet 
CAS 
PubMed 
PubMed Central 

Google Scholar 
Wang, M. & Huang, W. FOXS1 promotes prostate cancer progression through the Hedgehog/Gli1 pathway. Biochem. Pharmacol. 218, 115893 (2023).Article 
CAS 
PubMed 

Google Scholar 
Bora-Singhal, N. et al. Gli1-mediated regulation of Sox2 facilitates self-renewal of stem-like cells and confers resistance to EGFR inhibitors in non-small cell lung cancer. Neoplasia 17(7), 538–551 (2015).Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 
Niewiadomski, P. et al. Gli proteins: regulation in development and cancer. Cells 8(2), 147 (2019).Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 
Galvin, K. E. et al. Gli1 induces G2/M arrest and apoptosis in hippocampal but not tumor-derived neural stem cells. Stem Cells 26(4), 1027–1036 (2008).Article 
CAS 
PubMed 

Google Scholar 
Joost, S. et al. GLI1 inhibition promotes epithelial-to-mesenchymal transition in pancreatic cancer cells. Cancer Res. 72(1), 88–99 (2012).Article 
CAS 
PubMed 

Google Scholar 
Azarian, M. et al. Genotoxicity of noscapine nanosuspension prepared by microfluidic reactors on HepG2 cell line. Iran. J. Chem. Chem. Eng. 39(5), 145–155 (2020).CAS 

Google Scholar 
Roche. life science. Roche. Feb 2,2018]; Available from: https://www.lifescience.roche.com/global_en/products/high-pure-rna-isolation-kit.html.Livak, K. J. & Schmittgen, T. D. Analysis of relative gene expression data using real-time quantitative PCR and the 2−ΔΔCT method. Methods 25(4), 402–408 (2001).Article 
CAS 
PubMed 

Google Scholar 
Pfaffl, M. W. A new mathematical model for relative quantification in real-time RT–PCR. Nucleic Acids Res. 29(9), e45–e45 (2001).Article 
CAS 
PubMed 
PubMed Central 

Google Scholar