Structural response of G protein binding to the cyclodepsipeptide inhibitor FR900359 probed by NMR spectroscopy

Chem. Sci., 2024, 15,12939-12956DOI: 10.1039/D4SC01950D, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Christian Bonifer, Wiebke Hanke, Jonas Mühle, Frank Löhr, Johanna Becker-Baldus, Jessica Nagel, Gebhard F. X. Schertler, Christa E. Müller, Gabriele M. König, Daniel Hilger, Clemens GlaubitzThe selective Gq inhibitor FR900359 was probed by NMR spectroscopy bound to the membrane-anchored Gq heterotrimer, revealing its mode of membrane interaction, protein binding and allosteric protein response.The content of this RSS Feed (c) The Royal Society of Chemistry