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MethNet: a robust approach to identify regulatory hubs and their distal targets from cancer data

MethNet constructs regulatory networks using TCGA dataMost of the published epigenome-wide association studies (EWAS) have focused on links between differentially methylated regions and the...

AI-enabled ECG index for predicting left ventricular dysfunction in patients with ST-segment elevation myocardial infarction

Study design and populationThis retrospective study was designed to validate the prognostic value of an AI-enabled ECG derived probability index as a digital biomarker...

SANTO: a coarse-to-fine alignment and stitching method for spatial omics

SANTOIn general, each spatial omics dataset contains N cells/spots, and the spatial coordinates and omics feature expression profiles are denoted as ({{{{mathscr{S}}}}}{{{{mathscr{in }}}}}{{mathbb{R}}}^{Ntimes D})...

Single-cell technologies mark the dawn of a new era

From CNRS News Single-cell technologies for the analysis of genomic data enable scientists to better study tissue mechanisms and heterogeneity at the scale of a...

Explainable drug repurposing via path based knowledge graph completion

Knowledge graph drug repurposing backgroundGraphs are collections of objects (nodes) and the set of interactions (edges) between pairs of these objects30. Knowledge graphs ((mathscr...

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