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scCAD: Cluster decomposition-based anomaly detection for rare cell identification in single-cell expression data

Overview of scCADSingle-cell RNA sequencing data often consist of a diverse range of cell types, each characterized by specific functions and significant variations in...

A catalog of small proteins from the global microbiome

Collection of global metagenomic datasets and prediction of smORFsIn total, 63,410 publicly available global assembled metagenomes from the SPIRE database21 collection were used. Briefly,...

Text summarization for pharmaceutical sciences using hierarchical clustering with a weighted evaluation methodology

DatasetOur main dataset is in the domain of regulatory requirements, consisting of 227 parts of texts from publically available 38 regulatory documents33, and parts...

Reconstructing SARS-CoV-2 lineages from mixed wastewater sequencing data

Finding lineages in simulated readsSynthetically combined datasets with known frequencies are a valuable control and self-test when developing wastewater data analysis techniques. One such...

Delineating the stepwise millisecond allosteric activation mechanism of the class C GPCR dimer mGlu5

Extensive unbiased MD simulations uncover a stepwise inter-subunit rearrangement and milliseconds timescale during mGlu5 activationTwo full-length crystal structures of mGlu5 were available when we...

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