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Multi-omic lineage tracing predicts the transcriptional, epigenetic and genetic determinants of cancer evolution

MiceAll animal studies were conducted with the approval of the Italian Ministry of Health and in compliance with the Italian law (D.lgs. 26/2014), which...

Highly efficient modeling and optimization of neural fiber responses to electrical stimulation

Field models: pig and human vagus nerve stimulationWe implemented and simulated finite element models of pig and human vagus nerves with cuff electrodes using...

Herbarium collections remain essential in the age of community science

Ethics and inclusionThe lands that many now call Canada, are the stolen traditional territories of many diverse First Nations, Métis, and Inuit Peoples. We...

Leveraging multiple data types for improved compound-kinase bioactivity prediction

DataThe bioactivity data used in our experiments was retrieved from two public databases: ChEMBL3221 and PubChem24. We collected a total of 205,545 IC50 measurements...

Bergenin protects against osteoarthritis by inhibiting STAT3, NF-κB and Jun pathways and suppressing osteoclastogenesis

Preparation of compoundsBer was solubilized in dimethyl sulfoxide to achieve a 10 mM concentration and subsequently stored at − 80 °C for preservation. This compound was sourced from...

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