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Integrating plasma proteomics with genome-wide association data to identify novel drug targets for inflammatory bowel disease

Associated plasma proteins identified in PWASWe conducted a PWAS by integrating GWAS data of IBD, UC and CD with the data of 1,348 plasma...

CXCL9, IL2RB, and SPP1, potential diagnostic biomarkers in the co-morbidity pattern of atherosclerosis and non-alcoholic steatohepatitis

Chalasani, N. et al. The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver...

Intratumoral microbiome of adenoid cystic carcinomas and comparison with other head and neck cancers

Clinical characteristics of the cohortsFresh frozen primary tumors from 50 patients with ACC, stage 1–4, and no prior therapy at the time of surgery...

Building a translational cancer dependency map for The Cancer Genome Atlas

Predictive modeling of gene essentialityTo begin building the translational dependency maps, predictive models of gene essentiality were trained on genome-wide CRISPR-Cas9 knockout screens from...

From virtual patients to digital twins in immuno-oncology: lessons learned from mechanistic quantitative systems pharmacology modeling

Wong, C. H., Siah, K. W. & Lo, A. W. Estimation of clinical trial success rates and related parameters. Biostatistics 20, 273–286 (2019).Article  ...

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