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Molecular dynamics simulations involving different β-propeller mutations reported in Swiss and French patients correlate with their disease phenotypes

Mutation screeningA total of 177 single nucleotide polymorphisms (SNPs) obtained from the various databases were located within amino acid residues 1-451 of the αIIb...

Exploring the correlation between DNA methylation and biological age using an interpretable machine learning framework

DNA methylation dataThe DNA methylation data for this study contained a total of 10,296 samples, of which 7,833 were healthy samples, and 2,463 were...

Expanding drug targets for 112 chronic diseases using a machine learning-assisted genetic priority score

Construction of machine learning models to predict phecode diagnosesWe screened 3612 phecodes included in phecodeX to identify 336 phecodes corresponding to non-communicable chronic disease...

Accurate identification of locally aneuploid cells by incorporating cytogenetic information in single cell data analysis

Single-cell RNA sequencing (scRNA-seq) has greatly improved our ability to understand the cellular composition of the tissues and organs of interest, identify phenotype-associated cell...

Exploring seed characteristics and performance through advanced physico-chemical techniques

The EPR spectra of the wheat (A, B, C, and D) seeds are displayed in Fig. 2. Under the measurement condition of 1 mW, the...

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