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A deep learning method for simultaneous denoising and missing wedge reconstruction in cryogenic electron tomography

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In this section, we describe DeepDeWedge and evaluate its effectiveness on real and simulated data.The DeepDeWedge algorithmDeepDeWedge takes a single tilt series t as...
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MALDI imaging combined with two-photon microscopy reveals local differences in the heterogeneity of colorectal cancer

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Tumour sample collectionThe study cohort consists of human tumour tissues resected from patients with CRC (n = 14). The cohort has a balanced distribution of the...
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Probabilistic inference of epigenetic age acceleration from cellular dynamics

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Statics and reproducibilitySample sizes for model inference and validation were determined by the cohort sizes. Randomization and blinding were not applicable during data collection...
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Coordinated, multicellular patterns of transcriptional variation that stratify patient cohorts are revealed by tensor decomposition

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Kang, H. M. et al. Multiplexed droplet single-cell RNA-sequencing using natural genetic variation. Nat. Biotechnol. 36, 89–94 (2018).Article  CAS  ...
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SLU researchers use RNA sequencing to uncover sex-based differences in t-cell responses for lung cancer immunotherapy

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Researchers at Saint Louis University School of Medicine investigated differences in T-cell responses between male and female patients with lung cancer that may help...
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