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Autoregulated splicing of TRA2β programs T cell fate in response to antigen-receptor stimulation | Science

T cell receptor (TCR) sensitivity to peptide–major histocompatibility complex (MHC) dictates T cell fate. Canonical models of TCR sensitivity cannot be fully explained by...

Microbial dietary preference and interactions affect the export of lipids to the deep ocean

Submission historyReceived: 8 December 2023Accepted: 9 July 2024Published in print: 13 September 2024AcknowledgmentsWe thank R. Naisbit for help with editing the manuscript, N. Renier...

Exploiting the mechanical effects of ultrasound for noninvasive therapy | Science

Focused ultrasound is a platform technology capable of eliciting a wide range of biological responses with high spatial precision deep within the body. Although...

Transcripts of repetitive DNA elements signal to block phagocytosis of hematopoietic stem cells | Science

Macrophages maintain hematopoietic stem cell (HSC) quality by assessing cell surface Calreticulin (Calr), an “eat-me” signal induced by reactive oxygen species (ROS). Using zebrafish...

Teaching enzymes new reactions through genetic code expansion and directed evolution | Research

Can scientists design and engineer artificial enzymes to make the chemicals that society needs, with the selectivities and efficiencies of natural enzymes? That’s the...

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