Breast Cancer Association Consortium. Breast cancer risk genes—Association analysis in more than 113,000 women. N. EngI. J. 384, 428–439 (2021).ArticleÂ
Google ScholarÂ
Korde, L. A., Somerfield, M. R. & Hershman, D. L. Use of immune checkpoint inhibitor pembrolizumab in the treatment of high-risk, early-stage triple-negative breast cancer: ASCO guideline rapid recommendation update. JCO 40, 1696–1698 (2022).ArticleÂ
Google ScholarÂ
Moy, B., Rumble, R. B. & Carey, L. A. Chemotherapy and targeted therapy for endocrine-pretreated or hormone receptor-negative metastatic breast cancer: ASCO guideline rapid recommendation update. JCO 41, 1318–1320 (2023).ArticleÂ
CASÂ
Google ScholarÂ
Rizzo, A., Cusmai, A., Acquafredda, S., Rinaldi, L. & Palmiotti, G. Ladiratuzumab vedotin for metastatic triple negative cancer: Preliminary results, key challenges, and clinical potential. Expert Opin. Investig. Drugs 31, 495–498 (2022).ArticleÂ
CASÂ
PubMedÂ
Google ScholarÂ
Guven, D. C. et al. The association between albumin levels and survival in patients treated with immune checkpoint inhibitors: A systematic review and meta-analysis. Front. Mol. Biosci. 9, 2296–2889 (2022).ArticleÂ
Google ScholarÂ
Rizzo, A. et al. Hypertransaminasemia in cancer patients receiving immunotherapy and immune-based combinations: The MOUSEION-05 study. Cancer Immunol. Immunother. 72, 1381–1394 (2023).ArticleÂ
PubMedÂ
PubMed CentralÂ
Google ScholarÂ
Foulkes, W. D., Smith, I. E. & Reis-Filho, J. S. Triple-negative breast cancer. N. EngI. J. 363, 1938–1948 (2010).ArticleÂ
CASÂ
Google ScholarÂ
Li, S. D. & Huang, L. Pharmacokinetics and biodistribution of nanoparticles. Mol. Pharm. 5, 496–504 (2008).ArticleÂ
CASÂ
PubMedÂ
Google ScholarÂ
Bertrand, N., Wu, J., Xu, X. Y., Kamaly, N. & Farokhzad, O. C. Cancer nanotechnology: The impact of passive and active targeting in the era of modern cancer biology. Adv. Drug Deliv. Rev. 66, 2–25 (2014).ArticleÂ
CASÂ
PubMedÂ
Google ScholarÂ
Shi, J. J., Kantoff, P. W., Wooster, R. & Farokhzad, O. C. Cancer nanomedicine: Progress, challenges and opportunities. Nat. Rev. Cancer 17, 20–37 (2017).ArticleÂ
CASÂ
PubMedÂ
Google ScholarÂ
Zhu, G. H., Gray, A. B. C. & Patra, H. K. Nanomedicine: Controlling nanoparticle clearance for translational success. Trends Pharmacol. Sci. 43, 709–711 (2022).ArticleÂ
CASÂ
PubMedÂ
Google ScholarÂ
Mosleh-Shirazi, S., Abbasi, M., Shafiee, M., Kasaee, S. R. & Amani, A. M. Renal clearable nanoparticles: An expanding horizon for improving biomedical imaging and cancer therapy. Mater. Today Commun. 26, 102064 (2021).ArticleÂ
CASÂ
Google ScholarÂ
Xu, M. et al. Size-dependent in vivo transport of nanoparticles: Implications for delivery, targeting, and clearance. ACS Nano 17, 20825–20849 (2023).ArticleÂ
PubMedÂ
Google ScholarÂ
Bayda, S., Adeel, M., Tuccinardi, T., Cordani, M. & Rizzolio, F. The history of nanoscience and nanotechnology: From chemical-physical applications to nanomedicine. Molecules 25, 112 (2020).ArticleÂ
CASÂ
Google ScholarÂ
Rennick, J. J., Johnston, A. P. R. & Parton, R. G. Key principles and methods for studying the endocytosis of biological and nanoparticle therapeutics. Nat. Nanotechnol. 16, 266–276 (2021).ArticleÂ
ADSÂ
CASÂ
PubMedÂ
Google ScholarÂ
Harish, V. et al. Review on nanoparticles and nanostructured materials: Bioimaging, biosensing, drug delivery, tissue engineering, antimicrobial, and agro-food applications. Nanomaterials 12, 457 (2022).ArticleÂ
CASÂ
PubMedÂ
PubMed CentralÂ
Google ScholarÂ
Ouyang, J. et al. Minimally invasive nanomedicine: Nanotechnology in photo-/ultrasound-/radiation-/magnetism-mediated therapy and imaging. Chem. Soc. Rev. 51, 4996–5041 (2022).ArticleÂ
CASÂ
PubMedÂ
Google ScholarÂ
Li, T., Lu, X. M., Zhang, M. R., Hu, K. & Li, Z. Peptide-based nanomaterials: Self-assembly, properties and applications. Bioact. Mater. 11, 268–282 (2022).CASÂ
PubMedÂ
Google ScholarÂ
Overchuk, M., Weersink, R. A., Wilson, B. C. & Zheng, G. Photodynamic and photothermal therapies: Synergy opportunities for nanomedicine. ACS Nano 17, 7979–8003 (2023).ArticleÂ
CASÂ
PubMedÂ
PubMed CentralÂ
Google ScholarÂ
Liu, S., Pan, X. T. & Liu, H. Y. Two-dimensional nanomaterials for photothermal therapy. Angew. Chem. Int. Ed. 59, 5890–5900 (2020).ArticleÂ
CASÂ
Google ScholarÂ
Xu, C. et al. Metabolomics-derived biomarkers for biosafety assessment of Gd-based nanoparticle magnetic resonance imaging contrast agents. Analyst 149, 1169–1178 (2024).ArticleÂ
ADSÂ
CASÂ
PubMedÂ
Google ScholarÂ
Zhu, G. et al. Biosafety risk assessment of gold and aluminum nanoparticles in tumor-bearing mice. APL Bioeng. 7, 016116 (2023).ArticleÂ
CASÂ
PubMedÂ
PubMed CentralÂ
Google ScholarÂ
Stack, T. et al. Enhancing subcutaneous injection and target tissue accumulation of nanoparticles via co-administration with macropinocytosis inhibitory nanoparticles (MiNP). Nanoscale Horiz. 6, 393–400 (2021).ArticleÂ
ADSÂ
CASÂ
PubMedÂ
PubMed CentralÂ
Google ScholarÂ
Mills, J. A., Liu, F. F., Jarrett, T. R., Fletcher, N. L. & Thurecht, K. J. Nanoparticle based medicines: Approaches for evading and manipulating the mononuclear phagocyte system and potential for clinical translation. Biomater. Sci. 10, 3029–3053 (2022).ArticleÂ
CASÂ
PubMedÂ
Google ScholarÂ
Wang, L. et al. Exploring and analyzing the systemic delivery barriers for nanoparticles. Adv. Funct. Mater. 34, 2308446 (2023).ArticleÂ
PubMedÂ
Google ScholarÂ
Souri, M. et al. Towards principled design of cancer nanomedicine to accelerate clinical translation. Mater. Today Bio 13, 100208 (2022).ArticleÂ
ADSÂ
CASÂ
PubMedÂ
PubMed CentralÂ
Google ScholarÂ
Gustafson, H. H., Holt-Casper, D., Grainger, D. W. & Ghandehari, H. Nanoparticle uptake: The phagocyte problem. Nano Today 10, 487–510 (2015).ArticleÂ
CASÂ
PubMedÂ
PubMed CentralÂ
Google ScholarÂ
Verwilst, P., Park, S., Yoon, B. & Kim, J. S. Recent advances in Gd-chelate based bimodal optical/MRI contrast agents. Chem. Soc. Rev. 44, 1791–1806 (2015).ArticleÂ
CASÂ
PubMedÂ
Google ScholarÂ
Botta, M. & Tei, L. Relaxivity enhancement in macromolecular and nanosized GdIII-based MRI contrast agents. Eur. J. Inorg. Chem. 2012, 1945–1960 (2012).ArticleÂ
CASÂ
Google ScholarÂ
Lee, G. H., Chang, Y. M. & Kim, T. J. Blood-pool and targeting MRI contrast agents: From Gd-chelates to Gd-nanoparticles. Eur. J. Inorg. Chem. 2012, 1924–1933 (2012).ArticleÂ
CASÂ
Google ScholarÂ
Knopp, M. V., Tengg-Kobligk, H. V., Floemer, F. & Schoenberg, S. O. Contrast agents for MRA: Future directions. J. Magn. Reson. Imaging 10, 314–316 (1999).ArticleÂ
CASÂ
PubMedÂ
Google ScholarÂ
Yue, H., Park, J. Y., Chang, Y. M. & Lee, G. H. Ultrasmall europium, gadolinium, and dysprosium oxide nanoparticles: Polyol synthesis, properties, and biomedical imaging applications. Mini Rev. Med. Chem. 20, 1767–1780 (2020).ArticleÂ
CASÂ
PubMedÂ
Google ScholarÂ
Li, X. D., Sun, Y. H., Ma, L. N., Liu, G. F. & Wang, Z. X. The renal clearable magnetic resonance imaging contrast agents: State of the art and recent advances. Molecules 25, 5072 (2020).ArticleÂ
CASÂ
PubMedÂ
PubMed CentralÂ
Google ScholarÂ
Liu, F. Y., He, X. X., Zhang, J. P., Zhang, H. M. & Wang, Z. X. Employing tryptone as a general phase transfer agent to produce renal clearable nanodots for bioimaging. Small 11, 3676–3685 (2015).ArticleÂ
CASÂ
PubMedÂ
Google ScholarÂ
Yan, Y. N. et al. Renal-clearable hyaluronic acid functionalized NaGdF4 nanodots with enhanced tumor accumulation. RSC Adv. 10, 13872–13878 (2020).ArticleÂ
ADSÂ
CASÂ
PubMedÂ
PubMed CentralÂ
Google ScholarÂ
Kim, C. R. et al. Ligand-size dependent water proton relaxivities in ultrasmall gadolinium oxide nanoparticles and in vivo T1 MR images in a 1.5 T MR field. Phys. Chem. Chem. Phys. 16, 19866–19873 (2014).ArticleÂ
CASÂ
PubMedÂ
Google ScholarÂ
Ni, K. et al. Geometrically confined ultrasmall gadolinium oxide nanoparticles boost the T1 contrast ability. Nanoscale 8, 3768–3774 (2016).ArticleÂ
ADSÂ
CASÂ
PubMedÂ
Google ScholarÂ
Cheng, Z. L., Thorek, D. L. J. & Tsourkas, A. Gadolinium-conjugated dendrimer nanoclusters as a tumor-targeted T1 magnetic resonance imaging contrast agent. Angew. Chem. Int. Ed. 49, 346–350 (2010).ArticleÂ
CASÂ
Google ScholarÂ
Viger, M. L., Sankaranarayanan, J., Lux, C. D. G., Chan, M. & Almutairi, A. Collective activation of MRI agents via encapsulation and disease-triggered releas. J. Am. Chem. Soc. 135, 7847–7850 (2013).ArticleÂ
CASÂ
PubMedÂ
PubMed CentralÂ
Google ScholarÂ
Wang, J. et al. Detection of kidney dysfunction through in vivo magnetic resonance imaging with renal-clearable gadolinium nanoprobes. Anal. Chem. 94, 4005–4011 (2022).ArticleÂ
CASÂ
PubMedÂ
Google ScholarÂ
Chen, H. D., Li, X. D., Liu, F. Y., Zhang, H. M. & Wang, Z. X. Renal clearable peptide functionalized NaGdF4 nanodots for high-efficiency tracking orthotopic colorectal tumor in mouse. Mol. Pharm. 14, 3134–3141 (2017).ArticleÂ
CASÂ
PubMedÂ
Google ScholarÂ
Jiang, Z. L. et al. Boosting vascular imaging-performance and systemic biosafety of ultra-small NaGdF4 nanoparticles via surface engineering with rationally designed novel hydrophilic block co-polymer. Small Methods 6, 2101145 (2022).ArticleÂ
CASÂ
Google ScholarÂ
Xu, P. P. et al. Ultra-small albumin templated Gd/Ru composite nanodots for in vivo dual modal MR/thermal imaging guided photothermal therapy. Adv. Healthc. Mater. 7, 1800322 (2018).ArticleÂ
Google ScholarÂ
Nkandeu, D. S. et al. The involvement of a chemokine receptor antagonist CTCE-9908 and kynurenine metabolites in cancer development. Cell Biochem. Funct. 40, 608–622 (2022).ArticleÂ
CASÂ
PubMedÂ
Google ScholarÂ
Buck, A. K. et al. CXCR4-targeted theranostics in oncology. Eur. J. Nucl. Med. Mol. Imaging 49, 4133–4144 (2022).ArticleÂ
CASÂ
PubMedÂ
PubMed CentralÂ
Google ScholarÂ
Zhao, H. L. et al. CXCR4 over-expression and survival in cancer: A system review and meta-analysis. Oncotarget 6, 5022–5040 (2014).ArticleÂ
PubMed CentralÂ
Google ScholarÂ
Lippitz, B. E. Cytokine patterns in patients with cancer: A systematic review. Lancet Oncol. 14, 218–228 (2013).ArticleÂ
Google ScholarÂ
Song, N. et al. Advance in the role of chemokines/chemokine receptors in carcinogenesis: Focus on pancreatic cancer. Eur. J. Pharmacol. 967, 176357 (2024).ArticleÂ
CASÂ
PubMedÂ
Google ScholarÂ
Liu, G. F., Chen, H. D., Yu, S. N., Li, X. D. & Wang, Z. X. CXCR4 peptide conjugated Au–Fe2O3 Nanoparticles for tumor-targeting magnetic resonance imaging. Chem. Res. Chin. Univ. 34, 584–589 (2018).ArticleÂ
CASÂ
Google ScholarÂ
Meng, Y. L. et al. CXC chemokine receptor type 4 antagonistic gold nanorods induce specific immune responses and long-term immune memory to combat triple-negative breast cancer. ACS Appl. Mater. Interfaces 15, 18734–18746 (2023).ArticleÂ
CASÂ
PubMedÂ
Google ScholarÂ
Fu, Y. et al. CXC chemokine receptor 4 antagonist functionalized renal clearable manganese-doped iron oxide nanoparticles for active-tumor-targeting magnetic resonance imaging-guided bio-photothermal therapy. ACS Appl. Bio Mater. 2, 3613–3621 (2019).ArticleÂ
CASÂ
PubMedÂ
Google ScholarÂ
Bhattarai, S., Mackeyev, Y., Venkatesulu, B. P., Krishnanb, S. & Singh, P. K. CXC chemokine receptor 4 (CXCR4) targeted gold nanoparticles potently enhance radiotherapy outcomes in breast cancer. Nanoscale 13, 19056–19065 (2021).ArticleÂ
CASÂ
PubMedÂ
PubMed CentralÂ
Google ScholarÂ
Yang, C. et al. Biomimetic nanovaccines potentiating dendritic cell internalization via CXCR4-mediated macropinocytosis. Adv. Healthc. Mater. 12, 2202064 (2023).ArticleÂ
CASÂ
Google ScholarÂ
Johnson, N. J. J., Oakden, W., Stanisz, G. J., Prosser, R. S. & Veggel, F. C. J. M. V. Size-tunable, ultrasmall NaGdF4 nanoparticles: Insights into their T1 MRI contrast enhancement. Chem. Mater. 23, 3714–3722 (2011).ArticleÂ
CASÂ
Google ScholarÂ